E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects

E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects

Abstract Breast cancers (BC) are complex neo-organs composed of neoplastic as well as non-carcinogenic cells, in addition to a dynamic extracellular matrix. Active cancer-associated fibroblasts (CAFs) play major roles in the development and spread of breast cancers, through paracrine signaling, whic...

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Bibliographic Details
Main Authors: Layla A. Al-Kharashi, Falah H. Al-Mohanna, Abdelilah Aboussekhra, Abdelilah Abousekhra
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Breast cancer
Cancer-associated fibroblasts
Cancer stem cells
E2F1
EMT
Online Access:https://doi.org/10.1038/s41598-025-87808-9
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