Susceptibility Genes in Thyroid Autoimmunity
The autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520400008897 |
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| author | Yoshiyuki Ban Yaron Tomer |
| author_facet | Yoshiyuki Ban Yaron Tomer |
| author_sort | Yoshiyuki Ban |
| collection | DOAJ |
| description | The autoimmune thyroid diseases (AITD) are complex diseases which are
caused by an interaction between susceptibility genes and environmental
triggers. Genetic susceptibility in combination with external factors (e.g. dietary
iodine) is believed to initiate the autoimmune response to thyroid antigens.
Abundant epidemiological data, including family and twin studies, point to
a strong genetic influence on the development of AITD. Various techniques have
been employed to identify the genes contributing to the etiology of AITD, including
candidate gene analysis and whole genome screening. These studies have
enabled the identification of several loci (genetic regions) that are linked with
AITD, and in some of these loci, putative AITD susceptibility genes have been
identified. Some of these genes/loci are unique to Graves' disease (GD) and
Hashimoto's thyroiditis (HT) and some are common to both the diseases, indicating
that there is a shared genetic susceptibility to GD and HT. The putative GD and HT
susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4) and
thyroid specific genes (e.g. TSHR, Tg). Most likely,
these loci interact and their interactions may influence disease phenotype and severity. |
| format | Article |
| id | doaj-art-115de7a806044eb2bcfef4970e9750c0 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-115de7a806044eb2bcfef4970e9750c02025-02-03T01:27:49ZengWileyClinical and Developmental Immunology1740-25221740-25302005-01-01121475810.1080/17402520400008897Susceptibility Genes in Thyroid AutoimmunityYoshiyuki Ban0Yaron Tomer1Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USADivision of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, USAThe autoimmune thyroid diseases (AITD) are complex diseases which are caused by an interaction between susceptibility genes and environmental triggers. Genetic susceptibility in combination with external factors (e.g. dietary iodine) is believed to initiate the autoimmune response to thyroid antigens. Abundant epidemiological data, including family and twin studies, point to a strong genetic influence on the development of AITD. Various techniques have been employed to identify the genes contributing to the etiology of AITD, including candidate gene analysis and whole genome screening. These studies have enabled the identification of several loci (genetic regions) that are linked with AITD, and in some of these loci, putative AITD susceptibility genes have been identified. Some of these genes/loci are unique to Graves' disease (GD) and Hashimoto's thyroiditis (HT) and some are common to both the diseases, indicating that there is a shared genetic susceptibility to GD and HT. The putative GD and HT susceptibility genes include both immune modifying genes (e.g. HLA, CTLA-4) and thyroid specific genes (e.g. TSHR, Tg). Most likely, these loci interact and their interactions may influence disease phenotype and severity.http://dx.doi.org/10.1080/17402520400008897 |
| spellingShingle | Yoshiyuki Ban Yaron Tomer Susceptibility Genes in Thyroid Autoimmunity Clinical and Developmental Immunology |
| title | Susceptibility Genes in Thyroid Autoimmunity |
| title_full | Susceptibility Genes in Thyroid Autoimmunity |
| title_fullStr | Susceptibility Genes in Thyroid Autoimmunity |
| title_full_unstemmed | Susceptibility Genes in Thyroid Autoimmunity |
| title_short | Susceptibility Genes in Thyroid Autoimmunity |
| title_sort | susceptibility genes in thyroid autoimmunity |
| url | http://dx.doi.org/10.1080/17402520400008897 |
| work_keys_str_mv | AT yoshiyukiban susceptibilitygenesinthyroidautoimmunity AT yarontomer susceptibilitygenesinthyroidautoimmunity |