Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI
It is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers. Growing evidence suggests personality differences have an...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8820443 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560158743461888 |
|---|---|
| author | Yu Shi Shimin Huang Hongrui Zhan Yaping Wang Yanyan Zeng Guiyuan Cai Jianming Yang Wen Wu |
| author_facet | Yu Shi Shimin Huang Hongrui Zhan Yaping Wang Yanyan Zeng Guiyuan Cai Jianming Yang Wen Wu |
| author_sort | Yu Shi |
| collection | DOAJ |
| description | It is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers. Growing evidence suggests personality differences have an impact on both placebo and nocebo effects. However, previous studies have not reached a unified conclusion. We designed this study to explore the personality differences of functional magnetic resonance imaging (fMRI) signals in placebo response and nocebo response by using psychophysiological interaction (PPI) analysis. 30 healthy subjects underwent conditioning induction training to establish expectations of placebo effect and nocebo effect, and then, all subjects completed the following experimental procedures: (1) baseline scanning, (2) acute pain model establishment, (3) pain status scanning, and (4) pseudorandom scanning of block design of placebo response or nocebo response. Behavioral data were collected after each scan. The results of this study showed that (1) there were significant differences of VAS placebo intervention between the extrovert group and the introvert group (p=0.004); (2) there were significant differences of VAS nocebo intervention between the extrovert group and the introvert group (p=0.011); (3) there were significant differences between the VAS placebo intervention and VAS pain status (baseline) in both the extrovert group (p<0.001) and the introvert group (p=0.001); (4) there were significant differences between the VAS nocebo intervention and VAS pain status (baseline) in both the extrovert group (p=0.008) and the introvert group (p<0.001). Moreover, there were significant differences in the brain network for placebo and nocebo responses between different personalities. We found that (1) deactivation differences of the pain-related network and limbic system play an important role in personality differences associated with placebo analgesia and (2) differences of control of anxiety and activation of dorsolateral prefrontal cortex may cause the personality differences observed in nocebo hyperalgesia. |
| format | Article |
| id | doaj-art-115ba7754d7b451bad0e5feee73c12ba |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-115ba7754d7b451bad0e5feee73c12ba2025-02-03T01:28:18ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88204438820443Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRIYu Shi0Shimin Huang1Hongrui Zhan2Yaping Wang3Yanyan Zeng4Guiyuan Cai5Jianming Yang6Wen Wu7Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaDepartment of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, ChinaIt is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers. Growing evidence suggests personality differences have an impact on both placebo and nocebo effects. However, previous studies have not reached a unified conclusion. We designed this study to explore the personality differences of functional magnetic resonance imaging (fMRI) signals in placebo response and nocebo response by using psychophysiological interaction (PPI) analysis. 30 healthy subjects underwent conditioning induction training to establish expectations of placebo effect and nocebo effect, and then, all subjects completed the following experimental procedures: (1) baseline scanning, (2) acute pain model establishment, (3) pain status scanning, and (4) pseudorandom scanning of block design of placebo response or nocebo response. Behavioral data were collected after each scan. The results of this study showed that (1) there were significant differences of VAS placebo intervention between the extrovert group and the introvert group (p=0.004); (2) there were significant differences of VAS nocebo intervention between the extrovert group and the introvert group (p=0.011); (3) there were significant differences between the VAS placebo intervention and VAS pain status (baseline) in both the extrovert group (p<0.001) and the introvert group (p=0.001); (4) there were significant differences between the VAS nocebo intervention and VAS pain status (baseline) in both the extrovert group (p=0.008) and the introvert group (p<0.001). Moreover, there were significant differences in the brain network for placebo and nocebo responses between different personalities. We found that (1) deactivation differences of the pain-related network and limbic system play an important role in personality differences associated with placebo analgesia and (2) differences of control of anxiety and activation of dorsolateral prefrontal cortex may cause the personality differences observed in nocebo hyperalgesia.http://dx.doi.org/10.1155/2020/8820443 |
| spellingShingle | Yu Shi Shimin Huang Hongrui Zhan Yaping Wang Yanyan Zeng Guiyuan Cai Jianming Yang Wen Wu Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI Neural Plasticity |
| title | Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI |
| title_full | Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI |
| title_fullStr | Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI |
| title_full_unstemmed | Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI |
| title_short | Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI |
| title_sort | personality differences of brain networks in placebo analgesia and nocebo hyperalgesia a psychophysiological interaction ppi approach in fmri |
| url | http://dx.doi.org/10.1155/2020/8820443 |
| work_keys_str_mv | AT yushi personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT shiminhuang personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT hongruizhan personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT yapingwang personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT yanyanzeng personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT guiyuancai personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT jianmingyang personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri AT wenwu personalitydifferencesofbrainnetworksinplaceboanalgesiaandnocebohyperalgesiaapsychophysiologicalinteractionppiapproachinfmri |