Calculated plasma volume status in hemodialysis patients
Background Plasma volume (PV) calculated from hematocrit and body weight has applications in cardiovascular disease. The current study investigated the validity of the calculated PV for predicting volume overload and its prognostic utility in patients undergoing hemodialysis (HD).Patients and method...
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2322685 |
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| author | Qiankun Zhang Hang Fang Lie Jin |
| author_facet | Qiankun Zhang Hang Fang Lie Jin |
| author_sort | Qiankun Zhang |
| collection | DOAJ |
| description | Background Plasma volume (PV) calculated from hematocrit and body weight has applications in cardiovascular disease. The current study investigated the validity of the calculated PV for predicting volume overload and its prognostic utility in patients undergoing hemodialysis (HD).Patients and methods Fifty-four HD patients were prospectively enrolled, and their actual PV (aPV) and relative PV status (PVS) were calculated. Bioelectrical impedance analysis (BIA) with assessment of and total body water (TBW), intracellular water (ICW), extracellular water (ECW), and overhydration (OH) and routine blood examinations were performed before dialysis. A second cohort of 164 HD patients was retrospectively enrolled to evaluate the relationship between the calculated PVS and the outcome, with an endpoint of all-cause mortality.Results aPV was significantly associated with TBW, ICW, ECW, OH, and ECW/TBW (all p < 0.001), and most strongly with ECW (r = 0.83). aPV predicted the extent of volume overload with an AUC of 0.770 (p < 0.001), but PVS did not (AUC = 0.617, p = 0.091). Median follow-up time was 53 months, during the course of which 60 (36.58%) patients died. Values for PVS (12.94 ± 10.87% vs. 7.45 ± 5.90%, p = 0.024) and time-averaged PVS (12.83 ± 11.20 vs. 6.78 ± 6.22%, p < 0.001) were significantly increased in patients who died relative to those who survived. A value of time-averaged PVS >8.72% was significantly associated with an increased incidence of all-cause mortality (HR = 2.48, p = 0.0023).Conclusions aPV was most strongly associated with ECW measured using BIA. HD patients with higher time-averaged PVS had a higher rate of all-cause mortality. |
| format | Article |
| id | doaj-art-115776901b1b45e59d0cccae8d615329 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-115776901b1b45e59d0cccae8d6153292025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2322685Calculated plasma volume status in hemodialysis patientsQiankun Zhang0Hang Fang1Lie Jin2Division of Nephrology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui, ChinaDivision of Nephrology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui, ChinaDivision of Nephrology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui, ChinaBackground Plasma volume (PV) calculated from hematocrit and body weight has applications in cardiovascular disease. The current study investigated the validity of the calculated PV for predicting volume overload and its prognostic utility in patients undergoing hemodialysis (HD).Patients and methods Fifty-four HD patients were prospectively enrolled, and their actual PV (aPV) and relative PV status (PVS) were calculated. Bioelectrical impedance analysis (BIA) with assessment of and total body water (TBW), intracellular water (ICW), extracellular water (ECW), and overhydration (OH) and routine blood examinations were performed before dialysis. A second cohort of 164 HD patients was retrospectively enrolled to evaluate the relationship between the calculated PVS and the outcome, with an endpoint of all-cause mortality.Results aPV was significantly associated with TBW, ICW, ECW, OH, and ECW/TBW (all p < 0.001), and most strongly with ECW (r = 0.83). aPV predicted the extent of volume overload with an AUC of 0.770 (p < 0.001), but PVS did not (AUC = 0.617, p = 0.091). Median follow-up time was 53 months, during the course of which 60 (36.58%) patients died. Values for PVS (12.94 ± 10.87% vs. 7.45 ± 5.90%, p = 0.024) and time-averaged PVS (12.83 ± 11.20 vs. 6.78 ± 6.22%, p < 0.001) were significantly increased in patients who died relative to those who survived. A value of time-averaged PVS >8.72% was significantly associated with an increased incidence of all-cause mortality (HR = 2.48, p = 0.0023).Conclusions aPV was most strongly associated with ECW measured using BIA. HD patients with higher time-averaged PVS had a higher rate of all-cause mortality.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2322685Calculated plasma volumehemodialysisbioelectrical impedance analysisvolume overloadall-cause mortality |
| spellingShingle | Qiankun Zhang Hang Fang Lie Jin Calculated plasma volume status in hemodialysis patients Renal Failure Calculated plasma volume hemodialysis bioelectrical impedance analysis volume overload all-cause mortality |
| title | Calculated plasma volume status in hemodialysis patients |
| title_full | Calculated plasma volume status in hemodialysis patients |
| title_fullStr | Calculated plasma volume status in hemodialysis patients |
| title_full_unstemmed | Calculated plasma volume status in hemodialysis patients |
| title_short | Calculated plasma volume status in hemodialysis patients |
| title_sort | calculated plasma volume status in hemodialysis patients |
| topic | Calculated plasma volume hemodialysis bioelectrical impedance analysis volume overload all-cause mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2322685 |
| work_keys_str_mv | AT qiankunzhang calculatedplasmavolumestatusinhemodialysispatients AT hangfang calculatedplasmavolumestatusinhemodialysispatients AT liejin calculatedplasmavolumestatusinhemodialysispatients |