Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand
Abstract Considering the limited information on the impact of PM2.5 content on ocular health, a follow-up study was conducted on 50 healthy adults. Samples were collected twice, once before the PM2.5 exposure season and again after exposure. Daily PM2.5 concentration data was gathered from Thung Sat...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-77288-8 |
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| author | Sobia Kausar Phanika Tongchai Sumed Yadoung Shamsa Sabir Supansa Pata Woottichai Khamduang Kriangkrai Chawansuntati Supachai Yodkeeree Anurak Wongta Surat Hongsibsong |
| author_facet | Sobia Kausar Phanika Tongchai Sumed Yadoung Shamsa Sabir Supansa Pata Woottichai Khamduang Kriangkrai Chawansuntati Supachai Yodkeeree Anurak Wongta Surat Hongsibsong |
| author_sort | Sobia Kausar |
| collection | DOAJ |
| description | Abstract Considering the limited information on the impact of PM2.5 content on ocular health, a follow-up study was conducted on 50 healthy adults. Samples were collected twice, once before the PM2.5 exposure season and again after exposure. Daily PM2.5 concentration data was gathered from Thung Satok monitoring station. All subjects completed the self-structured ocular symptom questionnaire. The concentrations of 1-OHP were determined using HPLC-FLD. Logistic regression analysis investigated the relationship between PM2.5 toxicity and ocular symptoms. The findings revealed that daily PM2.5 concentrations surpassed the WHO-recommended range by around threefold. Exposure to PM2.5 significantly raised the likelihood of ocular redness (adjusted OR: 12.39, 95% CI), watering (adjusted OR: 2.56, 95% CI), and dryness (adjusted OR: 5.06, 95% CI). Additionally, these symptoms had an exposure-response relationship with increasing 1-OHP levels. Ocular symptoms worsened in frequency and severity during the high PM2.5 season, showing a strong link to elevated PM2.5 levels. Lymphocyte counts were also positively correlated with redness, watering, and dryness during high PM2.5 exposure. In conclusion, our study shows that subjects exposed to higher PM2.5 levels presented more significant ocular surface alterations. |
| format | Article |
| id | doaj-art-114f7f00a332421bbb2bdddd41380b6a |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-114f7f00a332421bbb2bdddd41380b6a2025-08-20T02:10:46ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-77288-8Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, ThailandSobia Kausar0Phanika Tongchai1Sumed Yadoung2Shamsa Sabir3Supansa Pata4Woottichai Khamduang5Kriangkrai Chawansuntati6Supachai Yodkeeree7Anurak Wongta8Surat Hongsibsong9School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversitySchool of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversitySchool of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversitySchool of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversityDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai UniversityDepartment of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai UniversityResearch Center for Molecular and Cell Biology, Research Institute for Health Sciences, Chiang Mai UniversityDepartment of Biochemistry, Faculty of Medicine, Chiang Mai UniversitySchool of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversitySchool of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai UniversityAbstract Considering the limited information on the impact of PM2.5 content on ocular health, a follow-up study was conducted on 50 healthy adults. Samples were collected twice, once before the PM2.5 exposure season and again after exposure. Daily PM2.5 concentration data was gathered from Thung Satok monitoring station. All subjects completed the self-structured ocular symptom questionnaire. The concentrations of 1-OHP were determined using HPLC-FLD. Logistic regression analysis investigated the relationship between PM2.5 toxicity and ocular symptoms. The findings revealed that daily PM2.5 concentrations surpassed the WHO-recommended range by around threefold. Exposure to PM2.5 significantly raised the likelihood of ocular redness (adjusted OR: 12.39, 95% CI), watering (adjusted OR: 2.56, 95% CI), and dryness (adjusted OR: 5.06, 95% CI). Additionally, these symptoms had an exposure-response relationship with increasing 1-OHP levels. Ocular symptoms worsened in frequency and severity during the high PM2.5 season, showing a strong link to elevated PM2.5 levels. Lymphocyte counts were also positively correlated with redness, watering, and dryness during high PM2.5 exposure. In conclusion, our study shows that subjects exposed to higher PM2.5 levels presented more significant ocular surface alterations.https://doi.org/10.1038/s41598-024-77288-8PM2.5OcularHealth1-OHP |
| spellingShingle | Sobia Kausar Phanika Tongchai Sumed Yadoung Shamsa Sabir Supansa Pata Woottichai Khamduang Kriangkrai Chawansuntati Supachai Yodkeeree Anurak Wongta Surat Hongsibsong Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand Scientific Reports PM2.5 Ocular Health 1-OHP |
| title | Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand |
| title_full | Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand |
| title_fullStr | Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand |
| title_full_unstemmed | Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand |
| title_short | Impact of fine particulate matter (PM2.5) on ocular health among people living in Chiang Mai, Thailand |
| title_sort | impact of fine particulate matter pm2 5 on ocular health among people living in chiang mai thailand |
| topic | PM2.5 Ocular Health 1-OHP |
| url | https://doi.org/10.1038/s41598-024-77288-8 |
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