Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries
Background: Preemptive analgesia involves the introduction of an analgesic regimen before the onset of surgical stimuli. Paracetamol and ketorolac are effective in blunting postoperative pain scores and opioid consumption, but their comparison, when used preemptively, has been less studied. The stud...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of Current Research in Scientific Medicine |
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| Online Access: | https://journals.lww.com/10.4103/jcrsm.jcrsm_129_23 |
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| author | Syed Najeebullah Khadri R Shankar Anand K Soundarya Priyadharsini T. Krishna Prasad |
| author_facet | Syed Najeebullah Khadri R Shankar Anand K Soundarya Priyadharsini T. Krishna Prasad |
| author_sort | Syed Najeebullah Khadri |
| collection | DOAJ |
| description | Background:
Preemptive analgesia involves the introduction of an analgesic regimen before the onset of surgical stimuli. Paracetamol and ketorolac are effective in blunting postoperative pain scores and opioid consumption, but their comparison, when used preemptively, has been less studied. The study aim to compare the clinical efficacy of intravenous (IV) paracetamol and IV ketorolac given preemptively, to blunt the postoperative pain among patients undergoing laparoscopic surgeries.
Materials and Methods:
This was a double-blinded randomized control study conducted on 48 patients undergoing laparoscopic surgeries, and they were allotted into groups of 24 each. Patients in Group 1 received an IV paracetamol infusion of 1 g over 10–15 min, 1 h before surgery. Group 2 received IV ketorolac 30 mg in 100 mL NS over 10–15 min, 1 h before surgery. The primary aim of the study was to monitor postoperative pain using the Visual Analog Scale (VAS). The secondary aim was to monitor the rescue analgesia with the opioid. Hemodynamics and sedation score were monitored every 2 h till 12 h postsurgery.
Results:
The mean time to the first rescue drug among the paracetamol group was lower and statistically significant (P < 0.05) compared to the ketorolac group. The pulse rate, VAS, mean systolic blood pressure (SBP), Mean arterial pressure (MAP), and sedation score among the paracetamol group were insignificant compared to the ketorolac group at different time intervals.
Conclusion:
Postoperatively, sedation was not significantly different between the groups. The pain score was significantly lower and the time to first rescue was significantly higher among the ketorolac group compared to the paracetamol group. The preemptive use of IV ketorolac provided better postoperative analgesia compared with IV paracetamol in patients undergoing elective laparoscopic surgeries. |
| format | Article |
| id | doaj-art-114e82fb02834e58bcdd6b6af82d9226 |
| institution | Kabale University |
| issn | 2542-6273 2455-3069 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Current Research in Scientific Medicine |
| spelling | doaj-art-114e82fb02834e58bcdd6b6af82d92262025-01-23T05:24:56ZengWolters Kluwer Medknow PublicationsJournal of Current Research in Scientific Medicine2542-62732455-30692024-01-01101384310.4103/jcrsm.jcrsm_129_23Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeriesSyed Najeebullah KhadriR Shankar AnandK Soundarya PriyadharsiniT. Krishna PrasadBackground: Preemptive analgesia involves the introduction of an analgesic regimen before the onset of surgical stimuli. Paracetamol and ketorolac are effective in blunting postoperative pain scores and opioid consumption, but their comparison, when used preemptively, has been less studied. The study aim to compare the clinical efficacy of intravenous (IV) paracetamol and IV ketorolac given preemptively, to blunt the postoperative pain among patients undergoing laparoscopic surgeries. Materials and Methods: This was a double-blinded randomized control study conducted on 48 patients undergoing laparoscopic surgeries, and they were allotted into groups of 24 each. Patients in Group 1 received an IV paracetamol infusion of 1 g over 10–15 min, 1 h before surgery. Group 2 received IV ketorolac 30 mg in 100 mL NS over 10–15 min, 1 h before surgery. The primary aim of the study was to monitor postoperative pain using the Visual Analog Scale (VAS). The secondary aim was to monitor the rescue analgesia with the opioid. Hemodynamics and sedation score were monitored every 2 h till 12 h postsurgery. Results: The mean time to the first rescue drug among the paracetamol group was lower and statistically significant (P < 0.05) compared to the ketorolac group. The pulse rate, VAS, mean systolic blood pressure (SBP), Mean arterial pressure (MAP), and sedation score among the paracetamol group were insignificant compared to the ketorolac group at different time intervals. Conclusion: Postoperatively, sedation was not significantly different between the groups. The pain score was significantly lower and the time to first rescue was significantly higher among the ketorolac group compared to the paracetamol group. The preemptive use of IV ketorolac provided better postoperative analgesia compared with IV paracetamol in patients undergoing elective laparoscopic surgeries.https://journals.lww.com/10.4103/jcrsm.jcrsm_129_23ketorolaclaparoscopic surgeriesparacetamolpostoperative analgesiapreemptive analgesia |
| spellingShingle | Syed Najeebullah Khadri R Shankar Anand K Soundarya Priyadharsini T. Krishna Prasad Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries Journal of Current Research in Scientific Medicine ketorolac laparoscopic surgeries paracetamol postoperative analgesia preemptive analgesia |
| title | Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| title_full | Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| title_fullStr | Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| title_full_unstemmed | Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| title_short | Comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| title_sort | comparison of postoperative analgesia by preemptive use of intravenous paracetamol and intravenous ketorolac in patients undergoing elective laparoscopic surgeries |
| topic | ketorolac laparoscopic surgeries paracetamol postoperative analgesia preemptive analgesia |
| url | https://journals.lww.com/10.4103/jcrsm.jcrsm_129_23 |
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