Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del
The antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300 mg/kg showed mar...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/618209 |
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| author | Isma'il Shittu Amlabu Emmanuel Andrew Jonathan Nok |
| author_facet | Isma'il Shittu Amlabu Emmanuel Andrew Jonathan Nok |
| author_sort | Isma'il Shittu |
| collection | DOAJ |
| description | The antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300 mg/kg showed markedly reduced parasitaemia bouts of 43.50% and a mean survival time of 28 days postinfection. The plant extract prevented a drastic reduction in PCV showing its efficacy in ameliorating anaemic conditions in Plasmodium berghei-infected mice. Histological examination of liver tissues of treated and untreated mice further supports the antimalaria potential of this plant. This observation validates the traditional use of this plant for the treatment of malaria. |
| format | Article |
| id | doaj-art-114da9aba9d44b0fa554ea273c4f228f |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-114da9aba9d44b0fa554ea273c4f228f2025-02-03T05:45:36ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/618209618209Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla DelIsma'il Shittu0Amlabu Emmanuel1Andrew Jonathan Nok2Department of Biochemistry, Ahmadu Bello University, Zaria, NigeriaDepartment of Biochemistry, Kogi State University, P.M.B 1008 Anyigba, NigeriaDepartment of Biochemistry, Ahmadu Bello University, Zaria, NigeriaThe antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300 mg/kg showed markedly reduced parasitaemia bouts of 43.50% and a mean survival time of 28 days postinfection. The plant extract prevented a drastic reduction in PCV showing its efficacy in ameliorating anaemic conditions in Plasmodium berghei-infected mice. Histological examination of liver tissues of treated and untreated mice further supports the antimalaria potential of this plant. This observation validates the traditional use of this plant for the treatment of malaria.http://dx.doi.org/10.1155/2011/618209 |
| spellingShingle | Isma'il Shittu Amlabu Emmanuel Andrew Jonathan Nok Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del Journal of Parasitology Research |
| title | Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del |
| title_full | Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del |
| title_fullStr | Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del |
| title_full_unstemmed | Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del |
| title_short | Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del |
| title_sort | antimalaria effect of the ethanolic stem bark extracts of ficus platyphylla del |
| url | http://dx.doi.org/10.1155/2011/618209 |
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