Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication
In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/471205 |
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| author | Paul H. Sugarbaker O. Anthony Stuart Christopher Eger |
| author_facet | Paul H. Sugarbaker O. Anthony Stuart Christopher Eger |
| author_sort | Paul H. Sugarbaker |
| collection | DOAJ |
| description | In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy. Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations. The increased exposure for mitomycin C was 96, and the increased exposure for doxorubicin was 241. When the clearance of chemotherapy from the thoracic cavity was compared to clearance from the abdomen and pelvis, there was a considerably more rapid clearance from the abdomen as compared to the thorax. The pharmacologic study of intrapleural chemotherapy in these patients provides a strong pharmacologic rationale for regional chemotherapy in this group of patients. |
| format | Article |
| id | doaj-art-114cf1648d67468c98f8cc34d3b70380 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-114cf1648d67468c98f8cc34d3b703802025-02-03T01:22:37ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/471205471205Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and DecorticationPaul H. Sugarbaker0O. Anthony Stuart1Christopher Eger2Washington Cancer Institute, MedStar Washington Hospital Center, Washington, DC 20010, USAWashington Cancer Institute, MedStar Washington Hospital Center, Washington, DC 20010, USAThoracic Oncology Center, MedStar Washington Hospital Center, Washington, DC 20010, USAIn patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We monitored the intrapleural and plasma levels of mitomycin C and doxorubicin by HPLC assay in order to determine the pharmacokinetic behavior of this intracavitary use of chemotherapy. Our results showed a persistent high concentration of intrapleural drug as compared to plasma concentrations. The increased exposure for mitomycin C was 96, and the increased exposure for doxorubicin was 241. When the clearance of chemotherapy from the thoracic cavity was compared to clearance from the abdomen and pelvis, there was a considerably more rapid clearance from the abdomen as compared to the thorax. The pharmacologic study of intrapleural chemotherapy in these patients provides a strong pharmacologic rationale for regional chemotherapy in this group of patients.http://dx.doi.org/10.1155/2012/471205 |
| spellingShingle | Paul H. Sugarbaker O. Anthony Stuart Christopher Eger Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication Gastroenterology Research and Practice |
| title | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication |
| title_full | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication |
| title_fullStr | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication |
| title_full_unstemmed | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication |
| title_short | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication |
| title_sort | pharmacokinetics of hyperthermic intrathoracic chemotherapy following pleurectomy and decortication |
| url | http://dx.doi.org/10.1155/2012/471205 |
| work_keys_str_mv | AT paulhsugarbaker pharmacokineticsofhyperthermicintrathoracicchemotherapyfollowingpleurectomyanddecortication AT oanthonystuart pharmacokineticsofhyperthermicintrathoracicchemotherapyfollowingpleurectomyanddecortication AT christophereger pharmacokineticsofhyperthermicintrathoracicchemotherapyfollowingpleurectomyanddecortication |