Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma
Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment app...
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Main Authors: | Erin E. Crotty, Aimee A. Sato, Mohamed S. Abdelbaki |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2025-02-01
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Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1520316/full |
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