Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity
Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at differen...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2014/839597 |
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| author | Seyed Jalal Hosseinimehr Seyed Amir Hossein Hosseini |
| author_facet | Seyed Jalal Hosseinimehr Seyed Amir Hossein Hosseini |
| author_sort | Seyed Jalal Hosseinimehr |
| collection | DOAJ |
| description | Background. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by 131I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against 131I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy. |
| format | Article |
| id | doaj-art-1140e70d9b6d419c8ea2521cfe88c1fd |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-1140e70d9b6d419c8ea2521cfe88c1fd2025-02-03T06:04:57ZengWileyJournal of Toxicology1687-81911687-82052014-01-01201410.1155/2014/839597839597Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine ToxicitySeyed Jalal Hosseinimehr0Seyed Amir Hossein Hosseini1Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, IranDepartment of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, IranBackground. In this study, the radiosensitizing effect of resveratrol as a natural product was investigated on cell toxicity induced by 131I in thyroid cancer cell. Methods. Human thyroid cancer cell and human nonmalignant fibroblast cell (HFFF2) were treated with 131I and/or resveratrol at different concentrations for 48 h. The cell proliferation was measured by determination of the percent of the survival cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results. Findings of this study show that resveratrol enhanced the cell death induced by 131I on thyroid cancer cell. Also, resveratrol exhibited a protective effect on normal cells against 131I toxicity. Conclusion. This result indicates a promising effect of resveratrol on improvement of cellular toxicity during iodine therapy.http://dx.doi.org/10.1155/2014/839597 |
| spellingShingle | Seyed Jalal Hosseinimehr Seyed Amir Hossein Hosseini Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity Journal of Toxicology |
| title | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
| title_full | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
| title_fullStr | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
| title_full_unstemmed | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
| title_short | Resveratrol Sensitizes Selectively Thyroid Cancer Cell to 131-Iodine Toxicity |
| title_sort | resveratrol sensitizes selectively thyroid cancer cell to 131 iodine toxicity |
| url | http://dx.doi.org/10.1155/2014/839597 |
| work_keys_str_mv | AT seyedjalalhosseinimehr resveratrolsensitizesselectivelythyroidcancercellto131iodinetoxicity AT seyedamirhosseinhosseini resveratrolsensitizesselectivelythyroidcancercellto131iodinetoxicity |