Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis
Abstract BackgroundTelomere length (TL) is a marker of cellular health and aging. Physical exercise has been associated with longer telomeres and, therefore, healthier aging. However, results supporting such effects vary across studies. Our aim was to synthesize existing evide...
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| Format: | Article |
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JMIR Publications
2025-01-01
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| Series: | JMIR Aging |
| Online Access: | https://aging.jmir.org/2025/1/e64539 |
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| author | Juan Luis Sánchez-González Juan Luis Sánchez-Rodríguez Rogelio González-Sarmiento Víctor Navarro-López Raúl Juárez-Vela Jesús Pérez Javier Martín-Vallejo |
| author_facet | Juan Luis Sánchez-González Juan Luis Sánchez-Rodríguez Rogelio González-Sarmiento Víctor Navarro-López Raúl Juárez-Vela Jesús Pérez Javier Martín-Vallejo |
| author_sort | Juan Luis Sánchez-González |
| collection | DOAJ |
| description |
Abstract
BackgroundTelomere length (TL) is a marker of cellular health and aging. Physical exercise has been associated with longer telomeres and, therefore, healthier aging. However, results supporting such effects vary across studies. Our aim was to synthesize existing evidence on the effect of different modalities and durations of physical exercise on TL.
ObjectiveThe aim of this study was to explore the needs and expectations of individuals with physical disabilities and their interventionists for the use of a virtual reality physical activity platform in a community organization.
MethodsWe performed an umbrella review and meta-analysis. Data sources included PubMed, Embase, Web of Science, Cochrane Library, and Scopus. We selected systematic reviews and meta-analyses of randomized and nonrandomized controlled clinical trials evaluating the effect of physical exercise on TL.
ResultsOur literature search retrieved 12 eligible systematic reviews, 5 of which included meta-analyses. We identified 22 distinct primary studies to estimate the overall effect size of physical exercise on TL. The overall effect size was 0.28 (95% CI 0.118-0.439), with a heterogeneity test value Q of 43.08 (PIPP
ConclusionsOur umbrella review and meta-analysis detected a small-moderate positive effect of physical exercise on TL, which seems to be influenced by the duration and type of physical exercise. High quality studies looking into the impact of standardized, evidence-based physical exercise programs on TL are still warranted. |
| format | Article |
| id | doaj-art-111ce93213d44e398276c1718bd7c39b |
| institution | Kabale University |
| issn | 2561-7605 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Aging |
| spelling | doaj-art-111ce93213d44e398276c1718bd7c39b2025-01-23T10:58:20ZengJMIR PublicationsJMIR Aging2561-76052025-01-018e64539e6453910.2196/64539Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-AnalysisJuan Luis Sánchez-Gonzálezhttp://orcid.org/0000-0002-4791-6513Juan Luis Sánchez-Rodríguezhttp://orcid.org/0000-0002-9406-0957Rogelio González-Sarmientohttp://orcid.org/0000-0002-2726-6795Víctor Navarro-Lópezhttp://orcid.org/0000-0003-1362-6312Raúl Juárez-Velahttp://orcid.org/0000-0003-3597-2048Jesús Pérezhttp://orcid.org/0000-0003-0740-190XJavier Martín-Vallejohttp://orcid.org/0000-0003-3962-7356 Abstract BackgroundTelomere length (TL) is a marker of cellular health and aging. Physical exercise has been associated with longer telomeres and, therefore, healthier aging. However, results supporting such effects vary across studies. Our aim was to synthesize existing evidence on the effect of different modalities and durations of physical exercise on TL. ObjectiveThe aim of this study was to explore the needs and expectations of individuals with physical disabilities and their interventionists for the use of a virtual reality physical activity platform in a community organization. MethodsWe performed an umbrella review and meta-analysis. Data sources included PubMed, Embase, Web of Science, Cochrane Library, and Scopus. We selected systematic reviews and meta-analyses of randomized and nonrandomized controlled clinical trials evaluating the effect of physical exercise on TL. ResultsOur literature search retrieved 12 eligible systematic reviews, 5 of which included meta-analyses. We identified 22 distinct primary studies to estimate the overall effect size of physical exercise on TL. The overall effect size was 0.28 (95% CI 0.118-0.439), with a heterogeneity test value Q of 43.08 (PIPP ConclusionsOur umbrella review and meta-analysis detected a small-moderate positive effect of physical exercise on TL, which seems to be influenced by the duration and type of physical exercise. High quality studies looking into the impact of standardized, evidence-based physical exercise programs on TL are still warranted.https://aging.jmir.org/2025/1/e64539 |
| spellingShingle | Juan Luis Sánchez-González Juan Luis Sánchez-Rodríguez Rogelio González-Sarmiento Víctor Navarro-López Raúl Juárez-Vela Jesús Pérez Javier Martín-Vallejo Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis JMIR Aging |
| title | Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis |
| title_full | Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis |
| title_fullStr | Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis |
| title_full_unstemmed | Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis |
| title_short | Effect of Physical Exercise on Telomere Length: Umbrella Review and Meta-Analysis |
| title_sort | effect of physical exercise on telomere length umbrella review and meta analysis |
| url | https://aging.jmir.org/2025/1/e64539 |
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