Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B
Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) wh...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/340725 |
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| author | Demet Toprak Sevliya Öcal Demir Eda Kepenekli Kadayifci Özden Türel Ahmet Soysal Mustafa Bakir |
| author_facet | Demet Toprak Sevliya Öcal Demir Eda Kepenekli Kadayifci Özden Türel Ahmet Soysal Mustafa Bakir |
| author_sort | Demet Toprak |
| collection | DOAJ |
| description | Central nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) who experienced recurrent Candida albicans meningitis. The patient was treated successfully with intravenous liposomal amphotericin B at first attack, but 25 days after discharge he was readmitted to hospital with symptoms of meningitis. Candida albicans was grown in CFS culture again and cranial magnetic resonance imaging (MRI) showed ventriculitis. We administered liposomal amphotericin B both intravenously and intraventricularly and favorable result was achieved without any adverse effects. Intraventricular amphotericin B may be considered for the treatment of recurrent CNS Candida infections in addition to intravenous administration. |
| format | Article |
| id | doaj-art-111626bd6d3d41189a0d28ee5fea4732 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-111626bd6d3d41189a0d28ee5fea47322025-02-03T00:59:09ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/340725340725Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin BDemet Toprak0Sevliya Öcal Demir1Eda Kepenekli Kadayifci2Özden Türel3Ahmet Soysal4Mustafa Bakir5Department of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyDepartment of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyDepartment of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyDepartment of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyDepartment of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyDepartment of Pediatrics, Marmara University School of Medicine, 3500 Istanbul, TurkeyCentral nervous system (CNS) infection with Candida is rare but significant because of its high morbidity and mortality. When present, it is commonly seen among immunocompromised and hospitalized patients. Herein, we describe a case of a four-year-old boy with acute lymphoblastic leukemia (ALL) who experienced recurrent Candida albicans meningitis. The patient was treated successfully with intravenous liposomal amphotericin B at first attack, but 25 days after discharge he was readmitted to hospital with symptoms of meningitis. Candida albicans was grown in CFS culture again and cranial magnetic resonance imaging (MRI) showed ventriculitis. We administered liposomal amphotericin B both intravenously and intraventricularly and favorable result was achieved without any adverse effects. Intraventricular amphotericin B may be considered for the treatment of recurrent CNS Candida infections in addition to intravenous administration.http://dx.doi.org/10.1155/2015/340725 |
| spellingShingle | Demet Toprak Sevliya Öcal Demir Eda Kepenekli Kadayifci Özden Türel Ahmet Soysal Mustafa Bakir Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B Case Reports in Infectious Diseases |
| title | Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B |
| title_full | Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B |
| title_fullStr | Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B |
| title_full_unstemmed | Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B |
| title_short | Recurrent Candida albicans Ventriculitis Treated with Intraventricular Liposomal Amphotericin B |
| title_sort | recurrent candida albicans ventriculitis treated with intraventricular liposomal amphotericin b |
| url | http://dx.doi.org/10.1155/2015/340725 |
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