In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species
Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a prom...
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2018-01-01
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| Series: | Global Journal of Environmental Science and Management |
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| author | M. Karkhane Yousefi M. Seyed Hashtroudi A. Mashinchian Moradi A.R. Ghasempour |
| author_facet | M. Karkhane Yousefi M. Seyed Hashtroudi A. Mashinchian Moradi A.R. Ghasempour |
| author_sort | M. Karkhane Yousefi |
| collection | DOAJ |
| description | Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity of fucoxanthin which is the most important carotenoid found in the marine brown seaweeds and diatoms. fucoxanthin has many properties (antioxidant, antibacterial, anticancer, antiobesity, anti-inflammatory and etc.) due to its unique structure. Samples with different concentrations (10, 25 and 50 µg/ml) and at various incubation times were collected (6, 24 and 48 hours) from four different species (Padina tenuis, Colpomenia sinuosa, Iyengaria stellate and Dictyota indica) of brown seaweeds from Qeshm Island, Persian Gulf. Moreover, the anticancer activity of fucoxanthin-containing extracts on breast cancer cells line and normal human skin fibroblast cells line was assessed by MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assay to specify the cytotoxic effects. The results showed that fucoxanthin extract from Dictyota. indica at 24-hour treatment and 50 µg/ml concentration has the most effective anticancer activity on the breast cancer cells line, without toxic effects to the normal cells. According to the obtained results, it seems that Dictyota. Indica is a good candidate for further analysis and can be introduced to the food and pharmaceutical industries. |
| format | Article |
| id | doaj-art-110fc6e9bae9421f856d027aa2df8fe4 |
| institution | Kabale University |
| issn | 2383-3572 2383-3866 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | GJESM Publisher |
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| series | Global Journal of Environmental Science and Management |
| spelling | doaj-art-110fc6e9bae9421f856d027aa2df8fe42025-02-02T10:56:12ZengGJESM PublisherGlobal Journal of Environmental Science and Management2383-35722383-38662018-01-0141819010.22034/gjesm.2018.04.01.00828761In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed speciesM. Karkhane Yousefi0M. Seyed Hashtroudi1A. Mashinchian Moradi2A.R. Ghasempour3Department of Marine Biology, School of Marine Science, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Marine Living Science, Iranian National Institute for Oceanography and Atmospheric Science, Tehran, IranDepartment of Marine Biology, School of Marine Science, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Medicinal Plant and Drug Research, Shahid Beheshti University, Tehran, IranBreast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity of fucoxanthin which is the most important carotenoid found in the marine brown seaweeds and diatoms. fucoxanthin has many properties (antioxidant, antibacterial, anticancer, antiobesity, anti-inflammatory and etc.) due to its unique structure. Samples with different concentrations (10, 25 and 50 µg/ml) and at various incubation times were collected (6, 24 and 48 hours) from four different species (Padina tenuis, Colpomenia sinuosa, Iyengaria stellate and Dictyota indica) of brown seaweeds from Qeshm Island, Persian Gulf. Moreover, the anticancer activity of fucoxanthin-containing extracts on breast cancer cells line and normal human skin fibroblast cells line was assessed by MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assay to specify the cytotoxic effects. The results showed that fucoxanthin extract from Dictyota. indica at 24-hour treatment and 50 µg/ml concentration has the most effective anticancer activity on the breast cancer cells line, without toxic effects to the normal cells. According to the obtained results, it seems that Dictyota. Indica is a good candidate for further analysis and can be introduced to the food and pharmaceutical industries.http://www.gjesm.net/article_28761_d3a36b45ee9ea4f61bc92c9361e5b649.pdfAnticancerColpomenia sinuosaDictyota indicaFucoxanthinIyengaria stellateMTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assayPadina tenuis |
| spellingShingle | M. Karkhane Yousefi M. Seyed Hashtroudi A. Mashinchian Moradi A.R. Ghasempour In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species Global Journal of Environmental Science and Management Anticancer Colpomenia sinuosa Dictyota indica Fucoxanthin Iyengaria stellate MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assay Padina tenuis |
| title | In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| title_full | In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| title_fullStr | In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| title_full_unstemmed | In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| title_short | In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| title_sort | in vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species |
| topic | Anticancer Colpomenia sinuosa Dictyota indica Fucoxanthin Iyengaria stellate MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assay Padina tenuis |
| url | http://www.gjesm.net/article_28761_d3a36b45ee9ea4f61bc92c9361e5b649.pdf |
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