Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate
Curcumin (CRC) is a natural active principle with important anti-inflammatory, antioxidant, antibacterial, and antitumor properties but has some limitations, such as poor bioavailability, low water solubility, and rapid metabolism. To preserve CRC’s benefits and eliminate its limitations, novel CRC-...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Budapest University of Technology
2025-03-01
|
| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0013140&mi=cd |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590446357905408 |
|---|---|
| author | Delia Mihaela Raţă Anca Niculina Cadinoiu Luiza Mădălina Grădinaru Paul Codrin Fuioaga Gabriela Vochita Christelle Delaite Leonard Ionuţ Atanase |
| author_facet | Delia Mihaela Raţă Anca Niculina Cadinoiu Luiza Mădălina Grădinaru Paul Codrin Fuioaga Gabriela Vochita Christelle Delaite Leonard Ionuţ Atanase |
| author_sort | Delia Mihaela Raţă |
| collection | DOAJ |
| description | Curcumin (CRC) is a natural active principle with important anti-inflammatory, antioxidant, antibacterial, and antitumor properties but has some limitations, such as poor bioavailability, low water solubility, and rapid metabolism. To preserve CRC’s benefits and eliminate its limitations, novel CRC-loaded core-shell electrospun nanofibers were designed. The nanofibers were prepared by co-axial electrospinning method using poly(vinyl alcohol)/CRC as core and poly(vinyl alcohol)/sodium alginate as shell. Polymer coating protects the CRC, increasing its stability. The swelling degree of CRCloaded nanofibers at pH 5.4 was around 326% higher than at pH 7.4 (297%) due to the repulsions of the anion-anion COO–groups. The release efficiency of CRC at pH 7.4 was 81%, while at pH 5.4 was about 96%. In the first 6 h, there was a slower release of CRC from the nanofibers in both acidic and slightly alkaline environments. Nanofibers showed good hemocompatibility, the values being between 2.36–3.22% after the first 90 min of contact, and after 180 min of treatment, the degree of erythrocyte lysis was between 3.78 and 4.93%. Cell viability assay on V79-4 Chinese hamster fibroblasts demonstrated that treatment with free CRC led to a value of 39% whereas for CRC-loaded nanofibers, the cell viability value increased to 59.66%. The results of the present study indicated that CRC-loaded electrospun nanofibers can have great potential for biomedical applications. |
| format | Article |
| id | doaj-art-110782abf9d146939cf8b8b44034a5e1 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-110782abf9d146939cf8b8b44034a5e12025-01-23T14:54:55ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2025-03-0119323324510.3144/expresspolymlett.2025.18Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginateDelia Mihaela RaţăAnca Niculina CadinoiuLuiza Mădălina GrădinaruPaul Codrin FuioagaGabriela VochitaChristelle DelaiteLeonard Ionuţ AtanaseCurcumin (CRC) is a natural active principle with important anti-inflammatory, antioxidant, antibacterial, and antitumor properties but has some limitations, such as poor bioavailability, low water solubility, and rapid metabolism. To preserve CRC’s benefits and eliminate its limitations, novel CRC-loaded core-shell electrospun nanofibers were designed. The nanofibers were prepared by co-axial electrospinning method using poly(vinyl alcohol)/CRC as core and poly(vinyl alcohol)/sodium alginate as shell. Polymer coating protects the CRC, increasing its stability. The swelling degree of CRCloaded nanofibers at pH 5.4 was around 326% higher than at pH 7.4 (297%) due to the repulsions of the anion-anion COO–groups. The release efficiency of CRC at pH 7.4 was 81%, while at pH 5.4 was about 96%. In the first 6 h, there was a slower release of CRC from the nanofibers in both acidic and slightly alkaline environments. Nanofibers showed good hemocompatibility, the values being between 2.36–3.22% after the first 90 min of contact, and after 180 min of treatment, the degree of erythrocyte lysis was between 3.78 and 4.93%. Cell viability assay on V79-4 Chinese hamster fibroblasts demonstrated that treatment with free CRC led to a value of 39% whereas for CRC-loaded nanofibers, the cell viability value increased to 59.66%. The results of the present study indicated that CRC-loaded electrospun nanofibers can have great potential for biomedical applications.http://www.expresspolymlett.com/letolt.php?file=EPL-0013140&mi=cd electrospinning polysaccharide crosslinking crosslinking agent drug drug release hydrogel scaffold |
| spellingShingle | Delia Mihaela Raţă Anca Niculina Cadinoiu Luiza Mădălina Grădinaru Paul Codrin Fuioaga Gabriela Vochita Christelle Delaite Leonard Ionuţ Atanase Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate eXPRESS Polymer Letters electrospinning polysaccharide crosslinking crosslinking agent drug drug release hydrogel scaffold |
| title | Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate |
| title_full | Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate |
| title_fullStr | Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate |
| title_full_unstemmed | Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate |
| title_short | Design and characterization of curcumin-loaded electrospun nanofibers based on poly(vinyl alcohol) and sodium alginate |
| title_sort | design and characterization of curcumin loaded electrospun nanofibers based on poly vinyl alcohol and sodium alginate |
| topic | electrospinning polysaccharide crosslinking crosslinking agent drug drug release hydrogel scaffold |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0013140&mi=cd |
| work_keys_str_mv | AT deliamihaelarata designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT ancaniculinacadinoiu designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT luizamadalinagradinaru designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT paulcodrinfuioaga designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT gabrielavochita designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT christelledelaite designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate AT leonardionutatanase designandcharacterizationofcurcuminloadedelectrospunnanofibersbasedonpolyvinylalcoholandsodiumalginate |