The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity
Introduction. Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previou...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/4141579 |
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| author | Moerbono Mochtar Alamanda Murasmita M. Eko Irawanto Indah Julianto Harijono Kariosentono Fajar Waskito |
| author_facet | Moerbono Mochtar Alamanda Murasmita M. Eko Irawanto Indah Julianto Harijono Kariosentono Fajar Waskito |
| author_sort | Moerbono Mochtar |
| collection | DOAJ |
| description | Introduction. Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods. This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum. Result. Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. Conclusions. There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris. |
| format | Article |
| id | doaj-art-1103d841245f422eb3ee1053029249f9 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-1103d841245f422eb3ee1053029249f92025-02-03T05:45:08ZengWileyInternational Journal of Inflammation2090-80402042-00992018-01-01201810.1155/2018/41415794141579The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris SeverityMoerbono Mochtar0Alamanda Murasmita1M. Eko Irawanto2Indah Julianto3Harijono Kariosentono4Fajar Waskito5Dermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, IndonesiaDermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, IndonesiaDermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, IndonesiaDermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, IndonesiaDermatovenerology Department, Sebelas Maret University, Dr. Moewardi General Hospital, Surakarta, IndonesiaDermatovenerology Department, Gadjah Mada University, Dr. Sardjito’ General Hospital, Yogyakarta, IndonesiaIntroduction. Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods. This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum. Result. Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris. Conclusions. There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.http://dx.doi.org/10.1155/2018/4141579 |
| spellingShingle | Moerbono Mochtar Alamanda Murasmita M. Eko Irawanto Indah Julianto Harijono Kariosentono Fajar Waskito The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity International Journal of Inflammation |
| title | The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity |
| title_full | The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity |
| title_fullStr | The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity |
| title_full_unstemmed | The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity |
| title_short | The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity |
| title_sort | difference in interleukin 19 serum on degrees of acne vulgaris severity |
| url | http://dx.doi.org/10.1155/2018/4141579 |
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