The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis.

The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis.

<h4>Background</h4>Mutation of BRAF is a predominant event in cancers with poor prognosis such as melanoma and colorectal cancer. BRAF mutation leads to a constitutive activation of mitogen activated protein kinase pathway which is essential for cell proliferation and tumor progression....

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Main Authors: Gholamreza Safaee Ardekani, Seyed Mehdi Jafarnejad, Larry Tan, Ardavan Saeedi, Gang Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0047054&type=printable
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