Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures
The present study deals with experiments so as to highlight the solute (drug nimesulide) - solvent(water) interactions and related modifications in case of the presence of hydrotropic agents at different temperatures T(=298.15 to 313.15)K. Density and viscosity values of nimesulide have been determi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/625171 |
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| author | Chandravir S. Solanki Sushree Tripathy Minaketan Tripathy Upendra N. Dash |
| author_facet | Chandravir S. Solanki Sushree Tripathy Minaketan Tripathy Upendra N. Dash |
| author_sort | Chandravir S. Solanki |
| collection | DOAJ |
| description | The present study deals with experiments so as to highlight the solute (drug nimesulide) - solvent(water) interactions and related modifications in case of the presence of hydrotropic agents at different temperatures T(=298.15 to 313.15)K. Density and viscosity values of nimesulide have been determined in water in (0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2) mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K where as the solubility was studied at 308.15 K. From the density values, the limiting partial molar volumes and expansibilities have been calculated. The experimental viscosity values have been analyzed in terms of jones-dole equation and on the basis of transition theory for relative viscosity. |
| format | Article |
| id | doaj-art-10f3792af7da415e8b332a543fedccbd |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-10f3792af7da415e8b332a543fedccbd2025-02-03T05:44:52ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017S1S223S23010.1155/2010/625171Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different TemperaturesChandravir S. Solanki0Sushree Tripathy1Minaketan Tripathy2Upendra N. Dash3Indira Gandhi Institute of Pharmaceutical Sciences, Nayapalli, Bhubaneswar, IndiaFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, Selangor, 42300, MalaysiaFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, Selangor, 42300, MalaysiaDepartment of Chemistry, ITER, SOA University, Bhubanesawr, 751030, IndiaThe present study deals with experiments so as to highlight the solute (drug nimesulide) - solvent(water) interactions and related modifications in case of the presence of hydrotropic agents at different temperatures T(=298.15 to 313.15)K. Density and viscosity values of nimesulide have been determined in water in (0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2) mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K where as the solubility was studied at 308.15 K. From the density values, the limiting partial molar volumes and expansibilities have been calculated. The experimental viscosity values have been analyzed in terms of jones-dole equation and on the basis of transition theory for relative viscosity.http://dx.doi.org/10.1155/2010/625171 |
| spellingShingle | Chandravir S. Solanki Sushree Tripathy Minaketan Tripathy Upendra N. Dash Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures E-Journal of Chemistry |
| title | Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures |
| title_full | Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures |
| title_fullStr | Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures |
| title_full_unstemmed | Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures |
| title_short | Studies on the Solute Solvent Interaction of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures |
| title_sort | studies on the solute solvent interaction of nimesulide in aqueous solutions of hydrotropic agents at different temperatures |
| url | http://dx.doi.org/10.1155/2010/625171 |
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