A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clustering

A Rapid Assessment Approach for Skin Stratum‐Targeted Drug Delivery Systems Using Mass Spectrometry Imaging and Spatial Clustering

A novel mass spectrometry imaging (MSI)‐based concept that enables rapid visualization and evaluation of active pharmaceutical ingredient (API) distribution across skin layers following dermal delivery is presented. This approach integrates desorption electrospray ionization MSI with a newly develop...

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Main Authors: Ravit Yakobi Arancibia, Einav Bentov‐Arava, Anna Morshin, Jhonathan Elia, Hiba Natsheh, Yael Levi‐Kalisman, Rotem Ushki, Anna Elia, Elka Touitou, Katherine Margulis
Format: Article
Language:English
Published: Wiley-VCH 2025-08-01
Series:Small Science
Subjects:
dermal delivery
desorption electrospray ionization mass spectrometry imaging
ethosomes
microemulsion
skin layers
terbinafine
Online Access:https://doi.org/10.1002/smsc.202500061
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https://doi.org/10.1002/smsc.202500061

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