Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, e...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/1835195 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564519521484800 |
|---|---|
| author | Gaia Favero Lorenzo Franceschetti Francesca Bonomini Luigi Fabrizio Rodella Rita Rezzani |
| author_facet | Gaia Favero Lorenzo Franceschetti Francesca Bonomini Luigi Fabrizio Rodella Rita Rezzani |
| author_sort | Gaia Favero |
| collection | DOAJ |
| description | Inflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines. Melatonin, an endogenous indoleamine, is considered an important multitasking molecule with fundamental clinical applications. It is involved in mood modulation, sexual behavior, vasomotor control, and immunomodulation and influences energy metabolism; moreover, it acts as an oncostatic and antiaging molecule. Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome. |
| format | Article |
| id | doaj-art-10ed06fc04ec4678b39b449682731b78 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-10ed06fc04ec4678b39b449682731b782025-02-03T01:10:42ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/18351951835195Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome ActivationGaia Favero0Lorenzo Franceschetti1Francesca Bonomini2Luigi Fabrizio Rodella3Rita Rezzani4Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyAnatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyInflammation may be defined as the innate response to harmful stimuli such as pathogens, injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic state. The exact aetiology leading to the development of inflammation is not known, but a combination of genetic, epigenetic, and environmental factors seems to play an important role in the pathogenesis of many inflammation-related clinical conditions. Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines. Melatonin, an endogenous indoleamine, is considered an important multitasking molecule with fundamental clinical applications. It is involved in mood modulation, sexual behavior, vasomotor control, and immunomodulation and influences energy metabolism; moreover, it acts as an oncostatic and antiaging molecule. Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome.http://dx.doi.org/10.1155/2017/1835195 |
| spellingShingle | Gaia Favero Lorenzo Franceschetti Francesca Bonomini Luigi Fabrizio Rodella Rita Rezzani Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation International Journal of Endocrinology |
| title | Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation |
| title_full | Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation |
| title_fullStr | Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation |
| title_full_unstemmed | Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation |
| title_short | Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation |
| title_sort | melatonin as an anti inflammatory agent modulating inflammasome activation |
| url | http://dx.doi.org/10.1155/2017/1835195 |
| work_keys_str_mv | AT gaiafavero melatoninasanantiinflammatoryagentmodulatinginflammasomeactivation AT lorenzofranceschetti melatoninasanantiinflammatoryagentmodulatinginflammasomeactivation AT francescabonomini melatoninasanantiinflammatoryagentmodulatinginflammasomeactivation AT luigifabriziorodella melatoninasanantiinflammatoryagentmodulatinginflammasomeactivation AT ritarezzani melatoninasanantiinflammatoryagentmodulatinginflammasomeactivation |