Investigation of vitamin D deficiency in girls with growth and development variations—a single center study
PurposeTo understand the status of vitamin D deficiency in girls with growth and developmental variations, as well as the impact of COVID−19 on their vitamin D levels, and to provide reference for the prevention and treatment of vitamin D deficiency in children.MethodsA retrospective analysis was co...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1518548/full |
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| author | Panwang Huang Panwang Huang Beilei Zeng Beilei Zeng Feng Ren Yuan Zhou Yuan Zhou Ye Li Ye Li Yinyin Huang Yinyin Huang Xingyu Liu Xingyu Liu Jiaxiu Zhou Jiaxiu Zhou Yaping Ma Yaping Ma |
| author_facet | Panwang Huang Panwang Huang Beilei Zeng Beilei Zeng Feng Ren Yuan Zhou Yuan Zhou Ye Li Ye Li Yinyin Huang Yinyin Huang Xingyu Liu Xingyu Liu Jiaxiu Zhou Jiaxiu Zhou Yaping Ma Yaping Ma |
| author_sort | Panwang Huang |
| collection | DOAJ |
| description | PurposeTo understand the status of vitamin D deficiency in girls with growth and developmental variations, as well as the impact of COVID−19 on their vitamin D levels, and to provide reference for the prevention and treatment of vitamin D deficiency in children.MethodsA retrospective analysis was conducted on 1,345 instances of girls with growth and developmental variations who visited our pediatric endocrinology department and completed vitamin D detection. A total of 279 girls with complete data were included in this study. Among them, 246 girls were classified into four groups based on different growth and developmental variations: early puberty group, menarche group, obesity group, short stature group, and 33 healthy girls served as the control group. Besides, the girls were divided into pre-epidemic and post-epidemic groups by the occurrence of the COVID-19 epidemic. Vitamin D were measured in all girls. The 25(OH)D <20 ng/ml was used as the standard for vitamin D deficiency.ResultsThe levels of vitamin D in the early puberty group, menarche group, obesity group, short stature group, and control group were as follows: 20.23 ± 5.90 ng/ml, 17.85 ± 5.69 ng/ml, 21.31 ± 8.99 ng/ml, 27.90 ± 12.27 ng/ml, and 29.42 ± 12.65 ng/ml, respectively. The levels of vitamin D in the early puberty group, menarche group, and obesity group were significantly lower than those in the control group (P < 0.05). The individual vitamin D deficiency rates in the aforementioned groups were 52.07%, 73.91%, 59.46%, 30.95%, and 30.30%, respectively. The vitamin D levels in the pre-epidemic and post-epidemic groups were 20.48 ± 6.22 ng/ml and 22.50 ± 9.74 ng/ml, respectively (P > 0.05).ConclusionGirls with early puberty, menarche, and obesity have a certain deficiency of vitamin D levels, and appropriate vitamin D treatment should be provided clinically. Girls with short stature and healthy girls also have certain levels of vitamin D deficiency, and awareness of prevention should be strengthened. |
| format | Article |
| id | doaj-art-10e5fae67fbb4526843f06a5f7e6f13b |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-10e5fae67fbb4526843f06a5f7e6f13b2025-01-27T06:40:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15185481518548Investigation of vitamin D deficiency in girls with growth and development variations—a single center studyPanwang Huang0Panwang Huang1Beilei Zeng2Beilei Zeng3Feng Ren4Yuan Zhou5Yuan Zhou6Ye Li7Ye Li8Yinyin Huang9Yinyin Huang10Xingyu Liu11Xingyu Liu12Jiaxiu Zhou13Jiaxiu Zhou14Yaping Ma15Yaping Ma16Department of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaDepartment of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, ChinaLaboratory of Genomic and Precision Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, ChinaPurposeTo understand the status of vitamin D deficiency in girls with growth and developmental variations, as well as the impact of COVID−19 on their vitamin D levels, and to provide reference for the prevention and treatment of vitamin D deficiency in children.MethodsA retrospective analysis was conducted on 1,345 instances of girls with growth and developmental variations who visited our pediatric endocrinology department and completed vitamin D detection. A total of 279 girls with complete data were included in this study. Among them, 246 girls were classified into four groups based on different growth and developmental variations: early puberty group, menarche group, obesity group, short stature group, and 33 healthy girls served as the control group. Besides, the girls were divided into pre-epidemic and post-epidemic groups by the occurrence of the COVID-19 epidemic. Vitamin D were measured in all girls. The 25(OH)D <20 ng/ml was used as the standard for vitamin D deficiency.ResultsThe levels of vitamin D in the early puberty group, menarche group, obesity group, short stature group, and control group were as follows: 20.23 ± 5.90 ng/ml, 17.85 ± 5.69 ng/ml, 21.31 ± 8.99 ng/ml, 27.90 ± 12.27 ng/ml, and 29.42 ± 12.65 ng/ml, respectively. The levels of vitamin D in the early puberty group, menarche group, and obesity group were significantly lower than those in the control group (P < 0.05). The individual vitamin D deficiency rates in the aforementioned groups were 52.07%, 73.91%, 59.46%, 30.95%, and 30.30%, respectively. The vitamin D levels in the pre-epidemic and post-epidemic groups were 20.48 ± 6.22 ng/ml and 22.50 ± 9.74 ng/ml, respectively (P > 0.05).ConclusionGirls with early puberty, menarche, and obesity have a certain deficiency of vitamin D levels, and appropriate vitamin D treatment should be provided clinically. Girls with short stature and healthy girls also have certain levels of vitamin D deficiency, and awareness of prevention should be strengthened.https://www.frontiersin.org/articles/10.3389/fped.2025.1518548/fullgrowth and developmental variationsgirlsvitamin D deficiencyearly pubertymenarche |
| spellingShingle | Panwang Huang Panwang Huang Beilei Zeng Beilei Zeng Feng Ren Yuan Zhou Yuan Zhou Ye Li Ye Li Yinyin Huang Yinyin Huang Xingyu Liu Xingyu Liu Jiaxiu Zhou Jiaxiu Zhou Yaping Ma Yaping Ma Investigation of vitamin D deficiency in girls with growth and development variations—a single center study Frontiers in Pediatrics growth and developmental variations girls vitamin D deficiency early puberty menarche |
| title | Investigation of vitamin D deficiency in girls with growth and development variations—a single center study |
| title_full | Investigation of vitamin D deficiency in girls with growth and development variations—a single center study |
| title_fullStr | Investigation of vitamin D deficiency in girls with growth and development variations—a single center study |
| title_full_unstemmed | Investigation of vitamin D deficiency in girls with growth and development variations—a single center study |
| title_short | Investigation of vitamin D deficiency in girls with growth and development variations—a single center study |
| title_sort | investigation of vitamin d deficiency in girls with growth and development variations a single center study |
| topic | growth and developmental variations girls vitamin D deficiency early puberty menarche |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1518548/full |
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