A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder
Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs p...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/6956046 |
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| author | Rodney E. Shackelford Ekin Ozluk Jehan Abdulsattar Terry C. Lairmore Quyen Chu Eric X. Wei |
| author_facet | Rodney E. Shackelford Ekin Ozluk Jehan Abdulsattar Terry C. Lairmore Quyen Chu Eric X. Wei |
| author_sort | Rodney E. Shackelford |
| collection | DOAJ |
| description | Primary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs present with abdominal pain and jaundice and follow an aggressive course with patients surviving a median of 15 months following initial diagnosis. To our knowledge, we present the 16th case of a histologically pure LCNEC in a 62-year-old African American male who was successfully treated surgically. After discharge, he was subsequently lost to follow-up. Due to the extreme rarity of such disease entity, accurate diagnosis and proper management are essential for the best clinical outcome. |
| format | Article |
| id | doaj-art-10e34bdc351949c08530dc59a479b5b9 |
| institution | Kabale University |
| issn | 2090-6714 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-10e34bdc351949c08530dc59a479b5b92025-02-03T01:20:17ZengWileyCase Reports in Oncological Medicine2090-67142022-01-01202210.1155/2022/6956046A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the GallbladderRodney E. Shackelford0Ekin Ozluk1Jehan Abdulsattar2Terry C. Lairmore3Quyen Chu4Eric X. Wei5Department of PathologyDepartment of Pathology & Translational PathobiologyDepartment of Pathology & Translational PathobiologyDepartment of SurgeryDepartment of SurgeryDepartment of PathologyPrimary large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is a rare malignancy which is often associated with non-LCNEC histologic components. Histologically “pure” LCNECs of the gallbladder are exceedingly rare with only 15 cases reported in the medical literature. Clinically, LCNECs present with abdominal pain and jaundice and follow an aggressive course with patients surviving a median of 15 months following initial diagnosis. To our knowledge, we present the 16th case of a histologically pure LCNEC in a 62-year-old African American male who was successfully treated surgically. After discharge, he was subsequently lost to follow-up. Due to the extreme rarity of such disease entity, accurate diagnosis and proper management are essential for the best clinical outcome.http://dx.doi.org/10.1155/2022/6956046 |
| spellingShingle | Rodney E. Shackelford Ekin Ozluk Jehan Abdulsattar Terry C. Lairmore Quyen Chu Eric X. Wei A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder Case Reports in Oncological Medicine |
| title | A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder |
| title_full | A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder |
| title_fullStr | A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder |
| title_full_unstemmed | A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder |
| title_short | A Rare Case of Pure Primary Large Cell Neuroendocrine Carcinoma of the Gallbladder |
| title_sort | rare case of pure primary large cell neuroendocrine carcinoma of the gallbladder |
| url | http://dx.doi.org/10.1155/2022/6956046 |
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