Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients
The role of pre-transplant hypoalbuminemia and its impact on post-transplant outcomes in patients undergoing simultaneous pancreas-kidney (SPK) transplantation remains unclear. We analyzed all SPK recipients at our center, who had at least 2 weeks of pancreas and kidney graft survival and had serum...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14091/full |
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| author | Ekaterina Fedorova Sofia Nehring Firmino Dixon B. Kaufman Jon S. Odorico David Aufhauser Carrie Thiessen David P. Al-Adra Didier Mandelbrot Brad C. Astor Brad C. Astor Sandesh Parajuli |
| author_facet | Ekaterina Fedorova Sofia Nehring Firmino Dixon B. Kaufman Jon S. Odorico David Aufhauser Carrie Thiessen David P. Al-Adra Didier Mandelbrot Brad C. Astor Brad C. Astor Sandesh Parajuli |
| author_sort | Ekaterina Fedorova |
| collection | DOAJ |
| description | The role of pre-transplant hypoalbuminemia and its impact on post-transplant outcomes in patients undergoing simultaneous pancreas-kidney (SPK) transplantation remains unclear. We analyzed all SPK recipients at our center, who had at least 2 weeks of pancreas and kidney graft survival and had serum albumin measured within 45 days pre-transplant. Recipients were categorized based on pretransplant albumin level as normal (≥4.0 g/dL, N = 222, 42%), mild hypoalbuminemia (≥3.5–<4.0 g/dL, N = 190, 36%), and moderate hypoalbuminemia (<3.5 g/dL, N = 120, 23%). Kidney delayed graft function (DGF), length of stay (LOS) after transplant, re-hospitalization within 30 days after discharge, and need for a return to the operating room (OR) related to transplant surgical complications, acute rejection, and uncensored and death-censored graft failure, within the first years post-transplant were outcomes of interest. A total of 532 SPK recipients were included. Mild or moderate hypoalbuminemia was not associated with DGF, LOS, re-hospitalization, or return to the OR in unadjusted or adjusted analyses. Similarly, mild or moderate hypoalbuminemia was not associated with a risk of graft rejection or graft failure. Among SPK recipients, pre-transplant hypoalbuminemia was not associated with worse outcomes and should not be the determining factor in selecting patients for SPK transplant. |
| format | Article |
| id | doaj-art-10e27c75244f4191a3a6afb6635caae9 |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-10e27c75244f4191a3a6afb6635caae92025-01-20T15:30:44ZengFrontiers Media S.A.Transplant International1432-22772025-01-013810.3389/ti.2025.1409114091Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant RecipientsEkaterina Fedorova0Sofia Nehring Firmino1Dixon B. Kaufman2Jon S. Odorico3David Aufhauser4Carrie Thiessen5David P. Al-Adra6Didier Mandelbrot7Brad C. Astor8Brad C. Astor9Sandesh Parajuli10Division of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesUniversity of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, United StatesDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Transplant Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDepartment of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesDivision of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesThe role of pre-transplant hypoalbuminemia and its impact on post-transplant outcomes in patients undergoing simultaneous pancreas-kidney (SPK) transplantation remains unclear. We analyzed all SPK recipients at our center, who had at least 2 weeks of pancreas and kidney graft survival and had serum albumin measured within 45 days pre-transplant. Recipients were categorized based on pretransplant albumin level as normal (≥4.0 g/dL, N = 222, 42%), mild hypoalbuminemia (≥3.5–<4.0 g/dL, N = 190, 36%), and moderate hypoalbuminemia (<3.5 g/dL, N = 120, 23%). Kidney delayed graft function (DGF), length of stay (LOS) after transplant, re-hospitalization within 30 days after discharge, and need for a return to the operating room (OR) related to transplant surgical complications, acute rejection, and uncensored and death-censored graft failure, within the first years post-transplant were outcomes of interest. A total of 532 SPK recipients were included. Mild or moderate hypoalbuminemia was not associated with DGF, LOS, re-hospitalization, or return to the OR in unadjusted or adjusted analyses. Similarly, mild or moderate hypoalbuminemia was not associated with a risk of graft rejection or graft failure. Among SPK recipients, pre-transplant hypoalbuminemia was not associated with worse outcomes and should not be the determining factor in selecting patients for SPK transplant.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14091/fullhypoalbuminemiaSPKDGFpatient survivalgraft survival |
| spellingShingle | Ekaterina Fedorova Sofia Nehring Firmino Dixon B. Kaufman Jon S. Odorico David Aufhauser Carrie Thiessen David P. Al-Adra Didier Mandelbrot Brad C. Astor Brad C. Astor Sandesh Parajuli Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients Transplant International hypoalbuminemia SPK DGF patient survival graft survival |
| title | Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients |
| title_full | Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients |
| title_fullStr | Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients |
| title_full_unstemmed | Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients |
| title_short | Pre-Transplant Hypoalbuminemia Is Not Associated With Early Key Outcomes Among Simultaneous Pancreas and Kidney Transplant Recipients |
| title_sort | pre transplant hypoalbuminemia is not associated with early key outcomes among simultaneous pancreas and kidney transplant recipients |
| topic | hypoalbuminemia SPK DGF patient survival graft survival |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14091/full |
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