Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise
ABSTRACT Objective: To determine circulating endothelial progenitor cells (EPC) counts and levels of inflammatory markers in individuals with and without type 1 diabetes mellitus (T1DM) in response to an intense aerobic exercise session. Subjects and methods: In total, 15 adult men with T1DM and 1...
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Brazilian Society of Endocrinology and Metabolism
2025-01-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000300&lng=en&tlng=en |
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| author | Patrícia Martins Bock Raíssa Borges Monteiro Clara Krummenauer Maraschin Ana Paula Alegretti Mariela Granero Farias Fabiane Spagnol Patricia Luciana da Costa Lopez Lucas Porto Santos Lucas Helal Ruy Silveira Moraes Daniel Umpierre Beatriz D. Schaan |
| author_facet | Patrícia Martins Bock Raíssa Borges Monteiro Clara Krummenauer Maraschin Ana Paula Alegretti Mariela Granero Farias Fabiane Spagnol Patricia Luciana da Costa Lopez Lucas Porto Santos Lucas Helal Ruy Silveira Moraes Daniel Umpierre Beatriz D. Schaan |
| author_sort | Patrícia Martins Bock |
| collection | DOAJ |
| description | ABSTRACT Objective: To determine circulating endothelial progenitor cells (EPC) counts and levels of inflammatory markers in individuals with and without type 1 diabetes mellitus (T1DM) in response to an intense aerobic exercise session. Subjects and methods: In total, 15 adult men with T1DM and 15 healthy individuals underwent a 30-minute aerobic exercise session on a cycle ergometer at 60% of the peak heart rate. The EPC count (CD45dim/CD34+/KDR+), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) levels were measured before and 60 minutes after the session. Results: We found no difference within or between groups regarding EPC counts before and after the aerobic exercise: healthy individuals, 0.02% change (95% confidence interval [CI] −0.04%-0.08%); individuals with T1DM, 0.00% (95%CI −0.01%-0.01%). We also found no difference in TNF-α levels before and after exercise in healthy individuals (210.2, interquartile range [IQR] 142.1-401.2 pg/mL and 191.3, IQR 136.4-350.5 pg/mL, respectively) and in patients with T1DM (463.8, IQR 201.4-4306.0 pg/mL and 482.7, IQR 143.8-4304.3 pg/mL, respectively). Similarly, no difference in IL-6 levels was observed before and after exercise in healthy individuals (148.2, IQR 147.5-148.6 pg/mL and 148.2, IQR 147.7-148.6 pg/mL, respectively) and individuals with T1DM (147.2, IQR 145.9-147.7 pg/mL and 147.2, IQR 146.8-147.8 pg/mL, respectively). Conclusions: Patients with T1DM and healthy controls had comparable EPC responses to aerobic exercise, most likely due to the absence of a chronic inflammatory state. |
| format | Article |
| id | doaj-art-10db030b4cf249efafaa7fd841d18b11 |
| institution | Kabale University |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-10db030b4cf249efafaa7fd841d18b112025-01-21T07:45:45ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-01-0168spe110.20945/2359-4292-2023-0499Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercisePatrícia Martins Bockhttps://orcid.org/0000-0001-8572-3950Raíssa Borges Monteirohttps://orcid.org/0000-0003-4920-8112Clara Krummenauer Maraschinhttps://orcid.org/0000-0003-1728-8103Ana Paula Alegrettihttps://orcid.org/0000-0002-8444-4359Mariela Granero Fariashttps://orcid.org/0000-0002-4502-9312Fabiane Spagnolhttps://orcid.org/0000-0001-7669-2902Patricia Luciana da Costa Lopezhttps://orcid.org/0000-0002-0375-9181Lucas Porto Santoshttps://orcid.org/0000-0001-7934-0427Lucas Helalhttps://orcid.org/0000-0002-6900-7185Ruy Silveira Moraeshttps://orcid.org/0000-0001-6802-7128Daniel Umpierrehttps://orcid.org/0000-0001-6953-0163Beatriz D. Schaanhttps://orcid.org/0000-0002-2128-8387ABSTRACT Objective: To determine circulating endothelial progenitor cells (EPC) counts and levels of inflammatory markers in individuals with and without type 1 diabetes mellitus (T1DM) in response to an intense aerobic exercise session. Subjects and methods: In total, 15 adult men with T1DM and 15 healthy individuals underwent a 30-minute aerobic exercise session on a cycle ergometer at 60% of the peak heart rate. The EPC count (CD45dim/CD34+/KDR+), tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) levels were measured before and 60 minutes after the session. Results: We found no difference within or between groups regarding EPC counts before and after the aerobic exercise: healthy individuals, 0.02% change (95% confidence interval [CI] −0.04%-0.08%); individuals with T1DM, 0.00% (95%CI −0.01%-0.01%). We also found no difference in TNF-α levels before and after exercise in healthy individuals (210.2, interquartile range [IQR] 142.1-401.2 pg/mL and 191.3, IQR 136.4-350.5 pg/mL, respectively) and in patients with T1DM (463.8, IQR 201.4-4306.0 pg/mL and 482.7, IQR 143.8-4304.3 pg/mL, respectively). Similarly, no difference in IL-6 levels was observed before and after exercise in healthy individuals (148.2, IQR 147.5-148.6 pg/mL and 148.2, IQR 147.7-148.6 pg/mL, respectively) and individuals with T1DM (147.2, IQR 145.9-147.7 pg/mL and 147.2, IQR 146.8-147.8 pg/mL, respectively). Conclusions: Patients with T1DM and healthy controls had comparable EPC responses to aerobic exercise, most likely due to the absence of a chronic inflammatory state.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000300&lng=en&tlng=enTumor necrosis factor-alphainterleukin 6chemokine receptorsendothelium |
| spellingShingle | Patrícia Martins Bock Raíssa Borges Monteiro Clara Krummenauer Maraschin Ana Paula Alegretti Mariela Granero Farias Fabiane Spagnol Patricia Luciana da Costa Lopez Lucas Porto Santos Lucas Helal Ruy Silveira Moraes Daniel Umpierre Beatriz D. Schaan Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise Archives of Endocrinology and Metabolism Tumor necrosis factor-alpha interleukin 6 chemokine receptors endothelium |
| title | Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| title_full | Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| title_fullStr | Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| title_full_unstemmed | Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| title_short | Circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| title_sort | circulating endothelial progenitor cells and inflammatory markers in type 1 diabetes after an acute session of aerobic exercise |
| topic | Tumor necrosis factor-alpha interleukin 6 chemokine receptors endothelium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972024001000300&lng=en&tlng=en |
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