Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma
Background. Paeoniae Radix Alba (PRA), the root of the plant Paeonia lactiflora Pall., has been suggested to play an important role for the treatment of asthma. A biochemical understanding of the clinical effects of Paeoniae Radix Alba is needed. Here, we explore the phytochemicals and therapeutic m...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9659304 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556867576922112 |
|---|---|
| author | Jingwei Wang Ling Peng Lu Jin Huiying Fu Qiyang Shou |
| author_facet | Jingwei Wang Ling Peng Lu Jin Huiying Fu Qiyang Shou |
| author_sort | Jingwei Wang |
| collection | DOAJ |
| description | Background. Paeoniae Radix Alba (PRA), the root of the plant Paeonia lactiflora Pall., has been suggested to play an important role for the treatment of asthma. A biochemical understanding of the clinical effects of Paeoniae Radix Alba is needed. Here, we explore the phytochemicals and therapeutic mechanisms via a systematic and comprehensive network pharmacology analysis. Methods. Through TCMSP, PubChem, GeneCards database, and SwissTargetPrediction online tools, potential targets of active ingredients from PRA for the treatment of asthma were obtained. Cytoscape 3.7.2 was used to determine the target of active ingredients of PRA. Target protein interaction (PPI) network was constructed through the STRING database. The Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genes (KEGG) pathway enrichment analysis were analyzed through the biological information annotation database (DAVID). Results. Our results indicate that PRA contains 21 candidate active ingredients with the potential to treat asthma. The enrichment analysis of GO and KEGG pathways found that the treatment of asthma by PRA may be related to the process of TNF (tumor necrosis factor) release, which can regulate and inhibit multiple signaling pathways such as ceramide signaling. Conclusions. Our work provides a phytochemical basis and therapeutic mechanisms of PRA for the treatment of asthma, which provides new insights on further research on PRA. |
| format | Article |
| id | doaj-art-10d50e31294845199c0fa61b6428b7f5 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-10d50e31294845199c0fa61b6428b7f52025-02-03T05:44:09ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/96593049659304Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of AsthmaJingwei Wang0Ling Peng1Lu Jin2Huiying Fu3Qiyang Shou4Second Clinical Medical College, Zhejiang Chinese Medical University, ChinaDepartment of Respiratory Disease, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, ChinaSecond Clinical Medical College, Zhejiang Chinese Medical University, ChinaSecond Clinical Medical College, Zhejiang Chinese Medical University, ChinaSecond Clinical Medical College, Zhejiang Chinese Medical University, ChinaBackground. Paeoniae Radix Alba (PRA), the root of the plant Paeonia lactiflora Pall., has been suggested to play an important role for the treatment of asthma. A biochemical understanding of the clinical effects of Paeoniae Radix Alba is needed. Here, we explore the phytochemicals and therapeutic mechanisms via a systematic and comprehensive network pharmacology analysis. Methods. Through TCMSP, PubChem, GeneCards database, and SwissTargetPrediction online tools, potential targets of active ingredients from PRA for the treatment of asthma were obtained. Cytoscape 3.7.2 was used to determine the target of active ingredients of PRA. Target protein interaction (PPI) network was constructed through the STRING database. The Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genes (KEGG) pathway enrichment analysis were analyzed through the biological information annotation database (DAVID). Results. Our results indicate that PRA contains 21 candidate active ingredients with the potential to treat asthma. The enrichment analysis of GO and KEGG pathways found that the treatment of asthma by PRA may be related to the process of TNF (tumor necrosis factor) release, which can regulate and inhibit multiple signaling pathways such as ceramide signaling. Conclusions. Our work provides a phytochemical basis and therapeutic mechanisms of PRA for the treatment of asthma, which provides new insights on further research on PRA.http://dx.doi.org/10.1155/2021/9659304 |
| spellingShingle | Jingwei Wang Ling Peng Lu Jin Huiying Fu Qiyang Shou Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma Journal of Immunology Research |
| title | Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma |
| title_full | Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma |
| title_fullStr | Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma |
| title_full_unstemmed | Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma |
| title_short | Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma |
| title_sort | network pharmacology analysis of the identification of phytochemicals and therapeutic mechanisms of paeoniae radix alba for the treatment of asthma |
| url | http://dx.doi.org/10.1155/2021/9659304 |
| work_keys_str_mv | AT jingweiwang networkpharmacologyanalysisoftheidentificationofphytochemicalsandtherapeuticmechanismsofpaeoniaeradixalbaforthetreatmentofasthma AT lingpeng networkpharmacologyanalysisoftheidentificationofphytochemicalsandtherapeuticmechanismsofpaeoniaeradixalbaforthetreatmentofasthma AT lujin networkpharmacologyanalysisoftheidentificationofphytochemicalsandtherapeuticmechanismsofpaeoniaeradixalbaforthetreatmentofasthma AT huiyingfu networkpharmacologyanalysisoftheidentificationofphytochemicalsandtherapeuticmechanismsofpaeoniaeradixalbaforthetreatmentofasthma AT qiyangshou networkpharmacologyanalysisoftheidentificationofphytochemicalsandtherapeuticmechanismsofpaeoniaeradixalbaforthetreatmentofasthma |