Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications
The most promising approach in Tissue Engineering involves the seeding of porous, biocompatible/biodegradable scaffolds, with donor cells to promote tissue regeneration. Additive biomanufacturing processes are increasingly recognized as ideal techniques to produce 3D structures with optimal pore siz...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2009/239643 |
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| _version_ | 1832550118149062656 |
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| author | Marco Domingos Dinuccio Dinucci Stefania Cometa Michele Alderighi Paulo Jorge Bártolo Federica Chiellini |
| author_facet | Marco Domingos Dinuccio Dinucci Stefania Cometa Michele Alderighi Paulo Jorge Bártolo Federica Chiellini |
| author_sort | Marco Domingos |
| collection | DOAJ |
| description | The most promising approach in Tissue Engineering involves the seeding of porous, biocompatible/biodegradable scaffolds, with donor cells to promote tissue regeneration. Additive biomanufacturing processes are increasingly recognized as ideal techniques to produce 3D structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in-growing tissues. This paper presents a novel extrusion-based system to produce 3D scaffolds with controlled internal/external geometry for TE applications.The BioExtruder is a low-cost system that uses a proper fabrication code based on the ISO programming language enabling the fabrication of multimaterial scaffolds. Poly(ε-caprolactone) was the material chosen to produce porous scaffolds, made by layers of directionally aligned microfilaments. Chemical, morphological, and in vitro biological evaluation performed on the polymeric constructs revealed a high potential of the BioExtruder to produce 3D scaffolds with regular and reproducible macropore architecture, without inducing relevant chemical and biocompatibility alterations of the material. |
| format | Article |
| id | doaj-art-10d2a96e21954ea29a90353610e553b1 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-10d2a96e21954ea29a90353610e553b12025-02-03T06:07:31ZengWileyInternational Journal of Biomaterials1687-87871687-87952009-01-01200910.1155/2009/239643239643Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering ApplicationsMarco Domingos0Dinuccio Dinucci1Stefania Cometa2Michele Alderighi3Paulo Jorge Bártolo4Federica Chiellini5Department of Chemistry & Industrial Chemistry, University of Pisa, 56126 Pisa, ItalyDepartment of Chemistry & Industrial Chemistry, University of Pisa, 56126 Pisa, ItalyDepartment of Chemistry & Industrial Chemistry, University of Pisa, 56126 Pisa, ItalyDepartment of Chemistry & Industrial Chemistry, University of Pisa, 56126 Pisa, ItalyCenter for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria (IPL), 2414-016 Leiria, PortugalDepartment of Chemistry & Industrial Chemistry, University of Pisa, 56126 Pisa, ItalyThe most promising approach in Tissue Engineering involves the seeding of porous, biocompatible/biodegradable scaffolds, with donor cells to promote tissue regeneration. Additive biomanufacturing processes are increasingly recognized as ideal techniques to produce 3D structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in-growing tissues. This paper presents a novel extrusion-based system to produce 3D scaffolds with controlled internal/external geometry for TE applications.The BioExtruder is a low-cost system that uses a proper fabrication code based on the ISO programming language enabling the fabrication of multimaterial scaffolds. Poly(ε-caprolactone) was the material chosen to produce porous scaffolds, made by layers of directionally aligned microfilaments. Chemical, morphological, and in vitro biological evaluation performed on the polymeric constructs revealed a high potential of the BioExtruder to produce 3D scaffolds with regular and reproducible macropore architecture, without inducing relevant chemical and biocompatibility alterations of the material.http://dx.doi.org/10.1155/2009/239643 |
| spellingShingle | Marco Domingos Dinuccio Dinucci Stefania Cometa Michele Alderighi Paulo Jorge Bártolo Federica Chiellini Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications International Journal of Biomaterials |
| title | Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications |
| title_full | Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications |
| title_fullStr | Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications |
| title_full_unstemmed | Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications |
| title_short | Polycaprolactone Scaffolds Fabricated via Bioextrusion for Tissue Engineering Applications |
| title_sort | polycaprolactone scaffolds fabricated via bioextrusion for tissue engineering applications |
| url | http://dx.doi.org/10.1155/2009/239643 |
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