HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer

HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer

Abstract The current treatment of triple‐negative breast cancer (TNBC) is still primarily based on platinum‐based chemotherapy. However, TNBC cells frequently develop resistance to platinum and experience relapse after drug withdrawal. It is crucial to specifically target and eliminate cisplatin‐tol...

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Bibliographic Details
Main Authors: Xiaoniu He, Yuanpei Li, Jian Li, Yu Li, Sijie Chen, Xia Yan, Zhangrong Xie, Jiangfeng Du, Guoan Chen, Jianbo Song, Qi Mei
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
chemotherapy resistance
HDAC2
lactylation
METTL3
TNBC
Online Access:https://doi.org/10.1002/advs.202413121
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