Serotonergic Modulation of Conditioned Fear
Conditioned fear plays a key role in anxiety disorders as well as depression and other neuropsychiatric conditions. Understanding how neuromodulators drive the associated learning and memory processes, including memory consolidation, retrieval/expression, and extinction (recall), is essential in the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.6064/2012/821549 |
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| author | Judith R. Homberg |
| author_facet | Judith R. Homberg |
| author_sort | Judith R. Homberg |
| collection | DOAJ |
| description | Conditioned fear plays a key role in anxiety disorders as well as depression and other neuropsychiatric conditions. Understanding how neuromodulators drive the associated learning and memory processes, including memory consolidation, retrieval/expression, and extinction (recall), is essential in the understanding of (individual differences in vulnerability to) these disorders and their treatment. The human and rodent studies I review here together reveal, amongst others, that acute selective serotonin reuptake inhibitor (SSRI) treatment facilitates fear conditioning, reduces contextual fear, and increases cued fear, chronic SSRI treatment reduces both contextual and cued fear, 5-HT1A receptors inhibit the acquisition and expression of contextual fear, 5-HT2A receptors facilitates the consolidation of cued and contextual fear, inactivation of 5-HT2C receptors facilitate the retrieval of cued fear memory, the 5-HT3 receptor mediates contextual fear, genetically induced increases in serotonin levels are associated with increased fear conditioning, impaired cued fear extinction, or impaired extinction recall, and that genetically induced 5-HT depletion increases fear conditioning and contextual fear. Several explanations are presented to reconcile seemingly paradoxical relationships between serotonin levels and conditioned fear. |
| format | Article |
| id | doaj-art-10d22ad9ab5045a1855e0add381a1700 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-10d22ad9ab5045a1855e0add381a17002025-02-03T00:59:57ZengWileyScientifica2090-908X2012-01-01201210.6064/2012/821549821549Serotonergic Modulation of Conditioned FearJudith R. Homberg0Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Centre, Geert Grooteplein 21, Route 126, 6525 EZ Nijmegen, The NetherlandsConditioned fear plays a key role in anxiety disorders as well as depression and other neuropsychiatric conditions. Understanding how neuromodulators drive the associated learning and memory processes, including memory consolidation, retrieval/expression, and extinction (recall), is essential in the understanding of (individual differences in vulnerability to) these disorders and their treatment. The human and rodent studies I review here together reveal, amongst others, that acute selective serotonin reuptake inhibitor (SSRI) treatment facilitates fear conditioning, reduces contextual fear, and increases cued fear, chronic SSRI treatment reduces both contextual and cued fear, 5-HT1A receptors inhibit the acquisition and expression of contextual fear, 5-HT2A receptors facilitates the consolidation of cued and contextual fear, inactivation of 5-HT2C receptors facilitate the retrieval of cued fear memory, the 5-HT3 receptor mediates contextual fear, genetically induced increases in serotonin levels are associated with increased fear conditioning, impaired cued fear extinction, or impaired extinction recall, and that genetically induced 5-HT depletion increases fear conditioning and contextual fear. Several explanations are presented to reconcile seemingly paradoxical relationships between serotonin levels and conditioned fear.http://dx.doi.org/10.6064/2012/821549 |
| spellingShingle | Judith R. Homberg Serotonergic Modulation of Conditioned Fear Scientifica |
| title | Serotonergic Modulation of Conditioned Fear |
| title_full | Serotonergic Modulation of Conditioned Fear |
| title_fullStr | Serotonergic Modulation of Conditioned Fear |
| title_full_unstemmed | Serotonergic Modulation of Conditioned Fear |
| title_short | Serotonergic Modulation of Conditioned Fear |
| title_sort | serotonergic modulation of conditioned fear |
| url | http://dx.doi.org/10.6064/2012/821549 |
| work_keys_str_mv | AT judithrhomberg serotonergicmodulationofconditionedfear |