Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases
Abstract Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if the metastases are resectable. Unfortunately, there is no reliable preoperative or intraoperative prognostic indicator. This...
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2025-07-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12918 |
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| author | Kosuke Fujimoto Fumikazu Koyama Hirotoshi Kobayashi Kenjiro Kotake Masayasu Kawasaki Yukihide Kanemitsu Yusuke Kinugasa Hideki Ueno Kotaro Maeda Takeshi Suto Michio Itabashi Kimihiko Funahashi Heita Ozawa Shingo Noura Hideyuki Ishida Masayuki Ohue Tomomichi Kiyomatsu Soichiro Ishihara Keiji Koda Hideo Baba Kenji Kawada Yojiro Hashiguchi Takanori Goi Yuji Toiyama Naohiro Tomita Eiji Sunami Fumihiko Fujita Jun Watanabe Kenichi Hakamada Goro Nakayama Kenichi Sugihara Yoichi Ajioka |
| author_facet | Kosuke Fujimoto Fumikazu Koyama Hirotoshi Kobayashi Kenjiro Kotake Masayasu Kawasaki Yukihide Kanemitsu Yusuke Kinugasa Hideki Ueno Kotaro Maeda Takeshi Suto Michio Itabashi Kimihiko Funahashi Heita Ozawa Shingo Noura Hideyuki Ishida Masayuki Ohue Tomomichi Kiyomatsu Soichiro Ishihara Keiji Koda Hideo Baba Kenji Kawada Yojiro Hashiguchi Takanori Goi Yuji Toiyama Naohiro Tomita Eiji Sunami Fumihiko Fujita Jun Watanabe Kenichi Hakamada Goro Nakayama Kenichi Sugihara Yoichi Ajioka |
| author_sort | Kosuke Fujimoto |
| collection | DOAJ |
| description | Abstract Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if the metastases are resectable. Unfortunately, there is no reliable preoperative or intraoperative prognostic indicator. This study aimed to determine the prognostic significance of the preoperative Glasgow prognostic score (GPS) in colorectal cancer patients with synchronous peritoneal metastases. Methods We conducted a prospective study on 143 patients with colorectal cancer and concurrent peritoneal metastases. Our analysis included prognostic factors, such as the GPS, using data from the institutional observational study by the Japanese Society for Cancer of the Colon and Rectum. Results The 3‐year survival rates for the GPS0 or 1 and GPS2 groups were 32.7% and 14.3%, respectively, with a significantly worse prognosis in the GPS2 group (p = 0.003). Multivariate analysis identified GPS2 (p = 0.006) and the peritoneal cancer index (PCI) (p = 0.029) or the Japanese surgical peritoneal metastasis grade (p = 0.009) as independent poor prognostic factors. Additionally, the GPS0 or 1 group with total resection of peritoneal metastases had a significantly better prognosis than the non‐resection group (p < 0.001); however, there was no difference between the GPS2 group with total peritoneal resection and the non‐resection group (p = 0.713). Conclusions Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases. |
| format | Article |
| id | doaj-art-10ce8daceec640b397ec1e227cc32628 |
| institution | DOAJ |
| issn | 2475-0328 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
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| series | Annals of Gastroenterological Surgery |
| spelling | doaj-art-10ce8daceec640b397ec1e227cc326282025-08-20T03:14:51ZengWileyAnnals of Gastroenterological Surgery2475-03282025-07-019475076010.1002/ags3.12918Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastasesKosuke Fujimoto0Fumikazu Koyama1Hirotoshi Kobayashi2Kenjiro Kotake3Masayasu Kawasaki4Yukihide Kanemitsu5Yusuke Kinugasa6Hideki Ueno7Kotaro Maeda8Takeshi Suto9Michio Itabashi10Kimihiko Funahashi11Heita Ozawa12Shingo Noura13Hideyuki Ishida14Masayuki Ohue15Tomomichi Kiyomatsu16Soichiro Ishihara17Keiji Koda18Hideo Baba19Kenji Kawada20Yojiro Hashiguchi21Takanori Goi22Yuji Toiyama23Naohiro Tomita24Eiji Sunami25Fumihiko Fujita26Jun Watanabe27Kenichi Hakamada28Goro Nakayama29Kenichi Sugihara30Yoichi Ajioka31Department of Surgery Nara Medical University Kashihara JapanDepartment of Surgery Nara Medical University Kashihara JapanDepartment of Surgery Tokyo Metropolitan Hiroo Hospital Tokyo JapanDepartment of Surgery Sano City Hospital Tochigi JapanDepartment of Surgery Bell Land General Hospital Sakai JapanDepartment of Colorectal Surgery National Cancer Center Hospital Tokyo JapanDepartment of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo JapanDepartment of Surgery National Defense Medical College Tokorozawa JapanInternational Medical Center Fujita Health University Hospital Toyoake JapanDepartment of Gastroenterological Surgery Yamagata Prefectural Central Hospital Yamagata JapanDepartment of Surgery, Institute of Gastroenterology Tokyo Women's Medical University Tokyo JapanDepartment of General and Gastroenterological Surgery Toho University Omori Medical Center Tokyo JapanDepartment of Surgery Tochigi Cancer Center Utsunomiya JapanDepartment of Surgery Osaka Rosai Hospital Sakai JapanDepartment of Digestive Tract and General Surgery, Saitama Medical Center Saitama Medical University Kawagoe JapanDepartment of Gastroenterological Surgery Osaka International Cancer Institute Osaka JapanDepartment of Colorectal Surgery National Center for Global Health and Medicine Tokyo JapanDepartment of Surgical Oncology The University of Tokyo Hospital Tokyo JapanDepartment of Surgery Teikyo University Chiba Medical Center Ichihara JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences Kumamoto University Kumamoto JapanDepartment of Gastrointestinal Surgery, Graduate School of Medicine Kyoto University Kyoto JapanDepartment of Surgery Teikyo University School of Medicine Tokyo JapanFirst Department of Surgery University of Fukui Fukui JapanDepartment of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences Mie University Graduate School of Medicine Tsu Mie JapanDivision of Lower Gastrointestinal Surgery, Department of Gastroenterological Surgery Hyogo Medical University Nishinomiya Hyogo JapanDepartment of Surgery Kyorin University School of Medicine Tokyo JapanDepartment of Surgery Kurume University School of Medicine Kurume JapanDepartment of Surgery, Gastroenterological Center Yokohama City University Medical Center Yokohama JapanDepartment of Gastroenterological Surgery Hirosaki University Graduate School of Medicine Aomori JapanDepartment of Gastroenterological Surgery (Surgery II) Nagoya University Graduate School of Medicine Nagoya JapanTokyo Medical and Dental University Tokyo JapanDivision of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences Niigata University Niigata JapanAbstract Background Chemotherapy is the typical choice for treating colorectal cancer with synchronous peritoneal metastases. Nonetheless, surgical resection may be chosen if the metastases are resectable. Unfortunately, there is no reliable preoperative or intraoperative prognostic indicator. This study aimed to determine the prognostic significance of the preoperative Glasgow prognostic score (GPS) in colorectal cancer patients with synchronous peritoneal metastases. Methods We conducted a prospective study on 143 patients with colorectal cancer and concurrent peritoneal metastases. Our analysis included prognostic factors, such as the GPS, using data from the institutional observational study by the Japanese Society for Cancer of the Colon and Rectum. Results The 3‐year survival rates for the GPS0 or 1 and GPS2 groups were 32.7% and 14.3%, respectively, with a significantly worse prognosis in the GPS2 group (p = 0.003). Multivariate analysis identified GPS2 (p = 0.006) and the peritoneal cancer index (PCI) (p = 0.029) or the Japanese surgical peritoneal metastasis grade (p = 0.009) as independent poor prognostic factors. Additionally, the GPS0 or 1 group with total resection of peritoneal metastases had a significantly better prognosis than the non‐resection group (p < 0.001); however, there was no difference between the GPS2 group with total peritoneal resection and the non‐resection group (p = 0.713). Conclusions Preoperative GPS2 is an independent poor prognostic factor in patients with colorectal cancer and synchronous peritoneal metastases, and surgical resection does not improve prognosis in patients with GPS2. Preoperative GPSs may be used as indicators for surgical resection of synchronous peritoneal metastases.https://doi.org/10.1002/ags3.12918colorectal cancerGlasgow prognostic scoreindicatorsperitoneal metastasessurgical resection |
| spellingShingle | Kosuke Fujimoto Fumikazu Koyama Hirotoshi Kobayashi Kenjiro Kotake Masayasu Kawasaki Yukihide Kanemitsu Yusuke Kinugasa Hideki Ueno Kotaro Maeda Takeshi Suto Michio Itabashi Kimihiko Funahashi Heita Ozawa Shingo Noura Hideyuki Ishida Masayuki Ohue Tomomichi Kiyomatsu Soichiro Ishihara Keiji Koda Hideo Baba Kenji Kawada Yojiro Hashiguchi Takanori Goi Yuji Toiyama Naohiro Tomita Eiji Sunami Fumihiko Fujita Jun Watanabe Kenichi Hakamada Goro Nakayama Kenichi Sugihara Yoichi Ajioka Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases Annals of Gastroenterological Surgery colorectal cancer Glasgow prognostic score indicators peritoneal metastases surgical resection |
| title | Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| title_full | Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| title_fullStr | Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| title_full_unstemmed | Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| title_short | Clinical significance of preoperative Glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| title_sort | clinical significance of preoperative glasgow prognostic score in patients with colorectal cancer and synchronous peritoneal metastases |
| topic | colorectal cancer Glasgow prognostic score indicators peritoneal metastases surgical resection |
| url | https://doi.org/10.1002/ags3.12918 |
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