Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics
The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-...
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2017-04-01
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| Series: | Fracture and Structural Integrity |
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| Online Access: | http://www.gruppofrattura.it/pdf/rivista/numero40/numero_40_art_8.pdf |
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| author | Ilias Doulamis Despina N. Perrea Panagiotis E. Chatzistergos Athanasios S. Mitousoudis Stavros K. Kourkoulis |
| author_facet | Ilias Doulamis Despina N. Perrea Panagiotis E. Chatzistergos Athanasios S. Mitousoudis Stavros K. Kourkoulis |
| author_sort | Ilias Doulamis |
| collection | DOAJ |
| description | The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). Body mass and relevant biochemical parameters were measured for the duration of the experimental protocol (37 weeks). Mechanical strength of both femurs of each animal was assessed in-vitro based on three point bending tests. It was re¬vealed that exposure to high-fat diet led to significant increase of body mass and cholesterol levels and also to substantial changes in bone mor-phology and strength. Ultimate stress for the animals exposed to high-fat diet and those exposed to high-fat-diet and exercise was 25% and 24% lower compared to control, respectively. Exercise increased bone thickness by 15% compared to animals that were not exposed to exer¬cise. It was concluded that high-fat-diet ap¬pears to have a detrimental effect on bone biomechanics and strength. Exer¬cise reversed the reduction in bone thickness that appears to be induced by high-fat diet. However no statistically significant increase in bone strength was observed. |
| format | Article |
| id | doaj-art-10cbcca95fed4c89b9a24e028d51ef3f |
| institution | Kabale University |
| issn | 1971-8993 1971-8993 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | Gruppo Italiano Frattura |
| record_format | Article |
| series | Fracture and Structural Integrity |
| spelling | doaj-art-10cbcca95fed4c89b9a24e028d51ef3f2025-02-03T00:45:22ZengGruppo Italiano FratturaFracture and Structural Integrity1971-89931971-89932017-04-011140859410.3221/IGF-ESIS.40.08Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristicsIlias Doulamis0Despina N. Perrea1Panagiotis E. Chatzistergos 2Athanasios S. Mitousoudis3 Stavros K. Kourkoulis4Laboratory for Experimental Surgery and Surgical Research “N.S. Christeas”, National and Kapodistrian Universtiy of Athens, Medical School, Agiou Thoma str. 15B, 11527, Athens, Greece.Laboratory for Experimental Surgery and Surgical Research “N.S. Christeas”, National and Kapodistrian Universtiy of Athens, Medical School, Agiou Thoma str. 15B, 11527, Athens, Greece.School of Health Sciences and Education, Staffordshire University, Stoke-on-Trent, UK.Unit of Biomechanics, Department of Mechanics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15773, Athens, Greece.Unit of Biomechanics, Department of Mechanics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15773, Athens, Greece.The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). Body mass and relevant biochemical parameters were measured for the duration of the experimental protocol (37 weeks). Mechanical strength of both femurs of each animal was assessed in-vitro based on three point bending tests. It was re¬vealed that exposure to high-fat diet led to significant increase of body mass and cholesterol levels and also to substantial changes in bone mor-phology and strength. Ultimate stress for the animals exposed to high-fat diet and those exposed to high-fat-diet and exercise was 25% and 24% lower compared to control, respectively. Exercise increased bone thickness by 15% compared to animals that were not exposed to exer¬cise. It was concluded that high-fat-diet ap¬pears to have a detrimental effect on bone biomechanics and strength. Exer¬cise reversed the reduction in bone thickness that appears to be induced by high-fat diet. However no statistically significant increase in bone strength was observed.http://www.gruppofrattura.it/pdf/rivista/numero40/numero_40_art_8.pdfBone biomechanicsMiceFemurHigh-fat-dietThree-point bendingBending strength |
| spellingShingle | Ilias Doulamis Despina N. Perrea Panagiotis E. Chatzistergos Athanasios S. Mitousoudis Stavros K. Kourkoulis Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics Fracture and Structural Integrity Bone biomechanics Mice Femur High-fat-diet Three-point bending Bending strength |
| title | Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics |
| title_full | Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics |
| title_fullStr | Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics |
| title_full_unstemmed | Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics |
| title_short | Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics |
| title_sort | exercise as a mean to reverse the detrimental effect of high fat diet on bone s fracture characteristics |
| topic | Bone biomechanics Mice Femur High-fat-diet Three-point bending Bending strength |
| url | http://www.gruppofrattura.it/pdf/rivista/numero40/numero_40_art_8.pdf |
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