EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports)
In recent years increasing attention focuses on the concept of EBV-positive lymphoproliferative diseases related to primary or secondary immunodeficiency resulting from immunosuppressive therapy and persistent infections. Due to the progress of treatment methods in oncohematology and oncology this p...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Practical Medicine Publishing House
2018-10-01
|
| Series: | Клиническая онкогематология |
| Subjects: | |
| Online Access: | http://bloodjournal.ru/wp-content/uploads/2018/09/7-1.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849703444599799808 |
|---|---|
| author | АM Kovrigina |
| author_facet | АM Kovrigina |
| author_sort | АM Kovrigina |
| collection | DOAJ |
| description | In recent years increasing attention focuses on the concept of EBV-positive lymphoproliferative diseases related to primary or secondary immunodeficiency resulting from immunosuppressive therapy and persistent infections. Due to the progress of treatment methods in oncohematology and oncology this pathology also occurs as a delayed event when new surgical and therapeutic approaches are applied. The paper presents proof for the pathogenetic significance of Epstein-Barr virus (EBV) in the pathology under consideration with its various clinical manifestations and describes the evolution of knowledge on posttransplant lymphoproliferative disorders with their morphological classification underlying EBV+ lymphoproliferative diseases. The WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues revised in 2017 includes new forms of EBV+ lymphoproliferative diseases (mucocutaneous ulcer, T- and NK-cell childhood lymphoproliferative disorders including cutaneous and systemic forms of chronic active EBV infection) and EBV+ large B-cell lymphomas (unspecified and fibrin-associated diffuse large B-cell lymphomas). The paper summarizes major characteristics of these diseases and exemplifies them by the author’s own experience. |
| format | Article |
| id | doaj-art-10c03c7cba9b4e4db07a6dd14aa6f4ff |
| institution | DOAJ |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-10c03c7cba9b4e4db07a6dd14aa6f4ff2025-08-20T03:17:15ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392018-10-0111432633710.21320/2500-2139-2018-11-4-326-337EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports)АM Kovrigina0National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167In recent years increasing attention focuses on the concept of EBV-positive lymphoproliferative diseases related to primary or secondary immunodeficiency resulting from immunosuppressive therapy and persistent infections. Due to the progress of treatment methods in oncohematology and oncology this pathology also occurs as a delayed event when new surgical and therapeutic approaches are applied. The paper presents proof for the pathogenetic significance of Epstein-Barr virus (EBV) in the pathology under consideration with its various clinical manifestations and describes the evolution of knowledge on posttransplant lymphoproliferative disorders with their morphological classification underlying EBV+ lymphoproliferative diseases. The WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues revised in 2017 includes new forms of EBV+ lymphoproliferative diseases (mucocutaneous ulcer, T- and NK-cell childhood lymphoproliferative disorders including cutaneous and systemic forms of chronic active EBV infection) and EBV+ large B-cell lymphomas (unspecified and fibrin-associated diffuse large B-cell lymphomas). The paper summarizes major characteristics of these diseases and exemplifies them by the author’s own experience.http://bloodjournal.ru/wp-content/uploads/2018/09/7-1.pdfNK-cell lymphoproliferative diseasesEpstein-Barr virus (EBV)immunodeficiencyimmune imbalanceimmunosuppressionmorphology |
| spellingShingle | АM Kovrigina EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) Клиническая онкогематология NK-cell lymphoproliferative diseases Epstein-Barr virus (EBV) immunodeficiency immune imbalance immunosuppression morphology |
| title | EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) |
| title_full | EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) |
| title_fullStr | EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) |
| title_full_unstemmed | EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) |
| title_short | EBV-Positive Lymphoproliferative Diseases: A New Concept and Differential Diagnosis (Literature Review and Case Reports) |
| title_sort | ebv positive lymphoproliferative diseases a new concept and differential diagnosis literature review and case reports |
| topic | NK-cell lymphoproliferative diseases Epstein-Barr virus (EBV) immunodeficiency immune imbalance immunosuppression morphology |
| url | http://bloodjournal.ru/wp-content/uploads/2018/09/7-1.pdf |
| work_keys_str_mv | AT amkovrigina ebvpositivelymphoproliferativediseasesanewconceptanddifferentialdiagnosisliteraturereviewandcasereports |