ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease

Abstract Background Menopausal loss of neuroprotective estrogen is thought to contribute to the sex differences in Alzheimer’s disease (AD). Activation of estrogen receptor beta (ERβ) can be clinically relevant since it avoids the adverse systemic effects of ERα activation. However, very few studies...

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Bibliographic Details
Main Authors: Aphrodite Demetriou, Birgitta Lindqvist, Heba G. Ali, Mohamed M. Shamekh, Mukesh Varshney, Jose Inzunza, Silvia Maioli, Per Nilsson, Ivan Nalvarte
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Biology of Sex Differences
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Online Access:https://doi.org/10.1186/s13293-025-00711-w
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