Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients
Objectives. We sought to assess the comparative value of inflammatory markers on the occurrence of left ventricular systolic dysfunction (LVSD) after an acute coronary syndrome (ACS). Methods. During 2006–2008, 760 patients with an ACS were enrolled. C-reactive protein (CRP) and white blood cell (WB...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/826297 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550191631171584 |
|---|---|
| author | Panagiotis Aggelopoulos Christina Chrysohoou Christos Pitsavos Lambros Papadimitriou Catherine Liontou Demosthenes Panagiotakos Eleftherios Tsiamis Christodoulos Stefanadis |
| author_facet | Panagiotis Aggelopoulos Christina Chrysohoou Christos Pitsavos Lambros Papadimitriou Catherine Liontou Demosthenes Panagiotakos Eleftherios Tsiamis Christodoulos Stefanadis |
| author_sort | Panagiotis Aggelopoulos |
| collection | DOAJ |
| description | Objectives. We sought to assess the comparative value of inflammatory markers on the occurrence of left ventricular systolic dysfunction (LVSD) after an acute coronary syndrome (ACS). Methods. During 2006–2008, 760 patients with an ACS were enrolled. C-reactive protein (CRP) and white blood cell (WBC) count were measured during the first 12 hours of hospital admission. Results. CRP levels and WBC count were significantly higher in those who developed LVSD compared to those who did not. The analysis revealed that a 10 mg/dL increase of CRP levels and a 1000/𝜇L increase in WBC are associated with a 6% and a 7% increase in the likelihood of developing LVSD, respectively. Furthermore, WBC count at entry and CRP have almost the same predictive value for development of LVSD after an ACS (𝑅2=0.109 versus 𝑅2=0.093). Conclusions. Serum CRP levels and WBC count at entry are almost equally powerful independent predictors of LVSD, after an ACS. |
| format | Article |
| id | doaj-art-10b3e266da524728b263255d82ba31e0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-10b3e266da524728b263255d82ba31e02025-02-03T06:07:29ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/826297826297Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome PatientsPanagiotis Aggelopoulos0Christina Chrysohoou1Christos Pitsavos2Lambros Papadimitriou3Catherine Liontou4Demosthenes Panagiotakos5Eleftherios Tsiamis6Christodoulos Stefanadis7First Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceDepartment of Nutrition Science Dietetics, Harokopio University, 176 71 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 115 28 Athens, GreeceObjectives. We sought to assess the comparative value of inflammatory markers on the occurrence of left ventricular systolic dysfunction (LVSD) after an acute coronary syndrome (ACS). Methods. During 2006–2008, 760 patients with an ACS were enrolled. C-reactive protein (CRP) and white blood cell (WBC) count were measured during the first 12 hours of hospital admission. Results. CRP levels and WBC count were significantly higher in those who developed LVSD compared to those who did not. The analysis revealed that a 10 mg/dL increase of CRP levels and a 1000/𝜇L increase in WBC are associated with a 6% and a 7% increase in the likelihood of developing LVSD, respectively. Furthermore, WBC count at entry and CRP have almost the same predictive value for development of LVSD after an ACS (𝑅2=0.109 versus 𝑅2=0.093). Conclusions. Serum CRP levels and WBC count at entry are almost equally powerful independent predictors of LVSD, after an ACS.http://dx.doi.org/10.1155/2009/826297 |
| spellingShingle | Panagiotis Aggelopoulos Christina Chrysohoou Christos Pitsavos Lambros Papadimitriou Catherine Liontou Demosthenes Panagiotakos Eleftherios Tsiamis Christodoulos Stefanadis Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients Mediators of Inflammation |
| title | Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients |
| title_full | Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients |
| title_fullStr | Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients |
| title_full_unstemmed | Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients |
| title_short | Comparative Value of Simple Inflammatory Markers in the Prediction of Left Ventricular Systolic Dysfunction in Postacute Coronary Syndrome Patients |
| title_sort | comparative value of simple inflammatory markers in the prediction of left ventricular systolic dysfunction in postacute coronary syndrome patients |
| url | http://dx.doi.org/10.1155/2009/826297 |
| work_keys_str_mv | AT panagiotisaggelopoulos comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT christinachrysohoou comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT christospitsavos comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT lambrospapadimitriou comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT catherineliontou comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT demosthenespanagiotakos comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT eleftheriostsiamis comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients AT christodoulosstefanadis comparativevalueofsimpleinflammatorymarkersinthepredictionofleftventricularsystolicdysfunctioninpostacutecoronarysyndromepatients |