Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects
Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an ath...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1018796 |
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| author | Flávia De C. Cartolano Gabriela D. Dias Maria C. P. de Freitas Antônio M. Figueiredo Neto Nágila R. T. Damasceno |
| author_facet | Flávia De C. Cartolano Gabriela D. Dias Maria C. P. de Freitas Antônio M. Figueiredo Neto Nágila R. T. Damasceno |
| author_sort | Flávia De C. Cartolano |
| collection | DOAJ |
| description | Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. The impact of IR as a predictor of atherogenic lipoproteins was tested by logistic regression analysis in raw and adjusted models. Results. HDL-C and Apo AI were significantly lower in individuals with IR. Individuals with IR had a higher percentage of small HDL particles, lower percentage in the larger ones, and reduced frequency of phenotype A (IR = 62%; non-IR = 83%). IR individuals had reduced probability to have large HDL (OR = 0.213; CI = 0.999–0.457) and had twice more chances to show increased small HDL (OR = 2.486; CI = 1.341–7.051). IR was a significant predictor of small LDL (OR = 3.075; CI = 1.341–7.051) and atherogenic phenotype (OR = 3.176; CI = 1.469–6.867). Conclusion. IR, previously DM2 diagnosis, is a strong predictor of quantitative and qualitative features of lipoproteins directly associated with an increased atherogenic risk. |
| format | Article |
| id | doaj-art-10af5fe148ee447896cc78fa4a5b316f |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-10af5fe148ee447896cc78fa4a5b316f2025-02-03T06:05:59ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/10187961018796Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic SubjectsFlávia De C. Cartolano0Gabriela D. Dias1Maria C. P. de Freitas2Antônio M. Figueiredo Neto3Nágila R. T. Damasceno4Department of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, SP, BrazilDepartment of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, SP, BrazilDepartment of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, SP, BrazilDepartment of Experimental Physics, Institute of Physics, University of Sao Paulo, São Paulo, SP, BrazilDepartment of Nutrition, School of Public Health, University of Sao Paulo, São Paulo, SP, BrazilBackground. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. The impact of IR as a predictor of atherogenic lipoproteins was tested by logistic regression analysis in raw and adjusted models. Results. HDL-C and Apo AI were significantly lower in individuals with IR. Individuals with IR had a higher percentage of small HDL particles, lower percentage in the larger ones, and reduced frequency of phenotype A (IR = 62%; non-IR = 83%). IR individuals had reduced probability to have large HDL (OR = 0.213; CI = 0.999–0.457) and had twice more chances to show increased small HDL (OR = 2.486; CI = 1.341–7.051). IR was a significant predictor of small LDL (OR = 3.075; CI = 1.341–7.051) and atherogenic phenotype (OR = 3.176; CI = 1.469–6.867). Conclusion. IR, previously DM2 diagnosis, is a strong predictor of quantitative and qualitative features of lipoproteins directly associated with an increased atherogenic risk.http://dx.doi.org/10.1155/2017/1018796 |
| spellingShingle | Flávia De C. Cartolano Gabriela D. Dias Maria C. P. de Freitas Antônio M. Figueiredo Neto Nágila R. T. Damasceno Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects Journal of Diabetes Research |
| title | Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects |
| title_full | Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects |
| title_fullStr | Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects |
| title_full_unstemmed | Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects |
| title_short | Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects |
| title_sort | insulin resistance predicts atherogenic lipoprotein profile in nondiabetic subjects |
| url | http://dx.doi.org/10.1155/2017/1018796 |
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