Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers
Magnetic nanoparticles are indispensable in many biomedical applications, but it remains unclear how the composition and structure will influence the application specific performance. We consider two compositions, ferrite and cobalt ferrite, synthesized under conditions that create aggregated multi‐...
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Wiley-VCH
2025-02-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400410 |
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| author | Julie Borchers Kathryn Krycka Brianna Bosch‐Santos Eduardo de Lima Correa Anirudh Sharma Hayden Carlton Yanliu Dang Michael Donahue Cordula Grüttner Robert Ivkov Cindi L. Dennis |
| author_facet | Julie Borchers Kathryn Krycka Brianna Bosch‐Santos Eduardo de Lima Correa Anirudh Sharma Hayden Carlton Yanliu Dang Michael Donahue Cordula Grüttner Robert Ivkov Cindi L. Dennis |
| author_sort | Julie Borchers |
| collection | DOAJ |
| description | Magnetic nanoparticles are indispensable in many biomedical applications, but it remains unclear how the composition and structure will influence the application specific performance. We consider two compositions, ferrite and cobalt ferrite, synthesized under conditions that create aggregated multi‐core nanoparticles, called nanoflowers. Each nanoflower has an ionic surfactant or dextran to provide colloid stability in water. The composition, but not the coating, greatly impacts the heating output and the magnetic particle imaging tracer quality (with cobalt ferrite significantly reduced compared to ferrite). The cobalt ferrite nanoflowers have a core/shell structure with a reduced magnetization, which limits the effective magnetic anisotropy of the individual cobalt ferrite nanoflowers as well as the magnetic interactions among the nanoflowers. Both limitations significantly reduce the overall increase in the magnetic anisotropy with increasing magnetic field and consequently the nanoflowers’ efficacy for heating and imaging. Despite this, the formation of denser‐packed clusters and chains with external magnetic field in the ionic surfactant‐cobalt ferrite nanoflowers overcomes some of the shell's detrimental effects, resulting in better heating and imaging properties compared to the dextran‐cobalt ferrite. In short, the magnetic anisotropy dominates over physical and magnetic structure in the performance of the studied nanoflowers for heating and imaging applications. |
| format | Article |
| id | doaj-art-10aa5c03b5f24bcaacc1764e5f4d5ce0 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-10aa5c03b5f24bcaacc1764e5f4d5ce02025-02-04T08:10:21ZengWiley-VCHSmall Structures2688-40622025-02-0162n/an/a10.1002/sstr.202400410Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic NanoflowersJulie Borchers0Kathryn Krycka1Brianna Bosch‐Santos2Eduardo de Lima Correa3Anirudh Sharma4Hayden Carlton5Yanliu Dang6Michael Donahue7Cordula Grüttner8Robert Ivkov9Cindi L. Dennis10NIST Center for Neutron Research National Institute of Standards and Technology Gaithersburg MD 20899‐6102 USANIST Center for Neutron Research National Institute of Standards and Technology Gaithersburg MD 20899‐6102 USAMaterial Measurement Laboratory National Institute of Standards and Technology Gaithersburg MD 20899‐8552 USAMaterial Measurement Laboratory National Institute of Standards and Technology Gaithersburg MD 20899‐8552 USADepartment of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore MD 21231 USADepartment of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore MD 21231 USAMaterial Measurement Laboratory National Institute of Standards and Technology Gaithersburg MD 20899‐8552 USAInformation Technology Laboratory National Institute of Standards and Technology Gaithersburg MD 20899 USAmicromod Partikeltechnologie, GmbH 18057 Rostock GermanyDepartment of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore MD 21231 USAMaterial Measurement Laboratory National Institute of Standards and Technology Gaithersburg MD 20899‐8552 USAMagnetic nanoparticles are indispensable in many biomedical applications, but it remains unclear how the composition and structure will influence the application specific performance. We consider two compositions, ferrite and cobalt ferrite, synthesized under conditions that create aggregated multi‐core nanoparticles, called nanoflowers. Each nanoflower has an ionic surfactant or dextran to provide colloid stability in water. The composition, but not the coating, greatly impacts the heating output and the magnetic particle imaging tracer quality (with cobalt ferrite significantly reduced compared to ferrite). The cobalt ferrite nanoflowers have a core/shell structure with a reduced magnetization, which limits the effective magnetic anisotropy of the individual cobalt ferrite nanoflowers as well as the magnetic interactions among the nanoflowers. Both limitations significantly reduce the overall increase in the magnetic anisotropy with increasing magnetic field and consequently the nanoflowers’ efficacy for heating and imaging. Despite this, the formation of denser‐packed clusters and chains with external magnetic field in the ionic surfactant‐cobalt ferrite nanoflowers overcomes some of the shell's detrimental effects, resulting in better heating and imaging properties compared to the dextran‐cobalt ferrite. In short, the magnetic anisotropy dominates over physical and magnetic structure in the performance of the studied nanoflowers for heating and imaging applications.https://doi.org/10.1002/sstr.202400410magnetic anisotropymagnetic nanoparticlesnanoflowerssmall angle neutron scattering |
| spellingShingle | Julie Borchers Kathryn Krycka Brianna Bosch‐Santos Eduardo de Lima Correa Anirudh Sharma Hayden Carlton Yanliu Dang Michael Donahue Cordula Grüttner Robert Ivkov Cindi L. Dennis Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers Small Structures magnetic anisotropy magnetic nanoparticles nanoflowers small angle neutron scattering |
| title | Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers |
| title_full | Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers |
| title_fullStr | Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers |
| title_full_unstemmed | Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers |
| title_short | Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers |
| title_sort | magnetic anisotropy dominates over physical and magnetic structure in performance of magnetic nanoflowers |
| topic | magnetic anisotropy magnetic nanoparticles nanoflowers small angle neutron scattering |
| url | https://doi.org/10.1002/sstr.202400410 |
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