To Live or to Die: Prosurvival Activity of PPARγ in Cancers
The role of PPARγ in tumorigenesis is controversial. In this article, we review and analyze literature from the past decade that highlights the potential proneoplastic activity of PPARγ. We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression o...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/209629 |
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| _version_ | 1832549285381537792 |
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| author | Y. Lynn Wang Qi Miao |
| author_facet | Y. Lynn Wang Qi Miao |
| author_sort | Y. Lynn Wang |
| collection | DOAJ |
| description | The role of PPARγ in tumorigenesis is controversial. In this article, we review and analyze literature from the past decade that highlights the potential proneoplastic activity of PPARγ. We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression of PPARγ in human tumor versus normal tissues; (2) receptor-dependent proneoplastic effects; (3) impact of PPARγ and its agonists on tumors in animal models; (4) clinical trials of thiazolidinediones (TZDs) in human malignancies; (5) TZDs as chemopreventive agents in epidemiology studies. The focus is placed on the most relevant in vivo animal models and human data. In vitro cell line studies are included only when the effects are shown to be dependent on the PPARγ receptor. |
| format | Article |
| id | doaj-art-109bf8811fd14eefa8188e8f6b121954 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-109bf8811fd14eefa8188e8f6b1219542025-02-03T06:11:39ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/209629209629To Live or to Die: Prosurvival Activity of PPARγ in CancersY. Lynn Wang0Qi Miao1Molecular Hematopathology Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USAMolecular Hematopathology Laboratory, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USAThe role of PPARγ in tumorigenesis is controversial. In this article, we review and analyze literature from the past decade that highlights the potential proneoplastic activity of PPARγ. We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression of PPARγ in human tumor versus normal tissues; (2) receptor-dependent proneoplastic effects; (3) impact of PPARγ and its agonists on tumors in animal models; (4) clinical trials of thiazolidinediones (TZDs) in human malignancies; (5) TZDs as chemopreventive agents in epidemiology studies. The focus is placed on the most relevant in vivo animal models and human data. In vitro cell line studies are included only when the effects are shown to be dependent on the PPARγ receptor.http://dx.doi.org/10.1155/2008/209629 |
| spellingShingle | Y. Lynn Wang Qi Miao To Live or to Die: Prosurvival Activity of PPARγ in Cancers PPAR Research |
| title | To Live or to Die: Prosurvival Activity of PPARγ in Cancers |
| title_full | To Live or to Die: Prosurvival Activity of PPARγ in Cancers |
| title_fullStr | To Live or to Die: Prosurvival Activity of PPARγ in Cancers |
| title_full_unstemmed | To Live or to Die: Prosurvival Activity of PPARγ in Cancers |
| title_short | To Live or to Die: Prosurvival Activity of PPARγ in Cancers |
| title_sort | to live or to die prosurvival activity of pparγ in cancers |
| url | http://dx.doi.org/10.1155/2008/209629 |
| work_keys_str_mv | AT ylynnwang toliveortodieprosurvivalactivityofppargincancers AT qimiao toliveortodieprosurvivalactivityofppargincancers |