Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset
Sjogren’s syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic l...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2019/4813795 |
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| _version_ | 1832562999109353472 |
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| author | Richard Witas Ammon B. Peck Julian L. Ambrus Cuong Q. Nguyen |
| author_facet | Richard Witas Ammon B. Peck Julian L. Ambrus Cuong Q. Nguyen |
| author_sort | Richard Witas |
| collection | DOAJ |
| description | Sjogren’s syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development. |
| format | Article |
| id | doaj-art-109a0bbb25f74ee38d53db1a9d505319 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-109a0bbb25f74ee38d53db1a9d5053192025-02-03T01:21:14ZengWileyJournal of Immunology Research2314-88612314-71562019-01-01201910.1155/2019/48137954813795Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease OnsetRichard Witas0Ammon B. Peck1Julian L. Ambrus2Cuong Q. Nguyen3Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USADepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USADivision of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of Medicine, Buffalo, NY, USADepartment of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USASjogren’s syndrome (SS) is a chronic, progressive autoimmune disease featuring both organ-specific and systemic manifestations, the most frequent being dry mouth and dry eyes resulting from lymphocytic infiltration into the salivary and lacrimal glands. Like the related autoimmune disease systemic lupus erythematosus (SLE), SS patients and mouse models display accumulation of apoptotic cells and a Type I interferon (IFN) signature. Receptor tyrosine kinases (RTKs) of the Tyro3, Axl, and Mer (TAM) family are present on the surface of macrophages and dendritic cells and participate in phagocytosis of apoptotic cells (efferocytosis) and inhibition of Type I IFN signaling. This review examines the relationship between TAM receptor dysfunction and SS and explores the potential contributions of TAM defects on macrophages to SS development.http://dx.doi.org/10.1155/2019/4813795 |
| spellingShingle | Richard Witas Ammon B. Peck Julian L. Ambrus Cuong Q. Nguyen Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset Journal of Immunology Research |
| title | Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset |
| title_full | Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset |
| title_fullStr | Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset |
| title_full_unstemmed | Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset |
| title_short | Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease Onset |
| title_sort | sjogren s syndrome and tam receptors a possible contribution to disease onset |
| url | http://dx.doi.org/10.1155/2019/4813795 |
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