Interpretable protein-DNA interactions captured by structure-sequence optimization

Interpretable protein-DNA interactions captured by structure-sequence optimization

Sequence-specific DNA recognition underlies essential processes in gene regulation, yet methods for simultaneous predictions of genomic DNA recognition sites and their binding affinity remain lacking. Here, we present the Interpretable protein-DNA Energy Associative (IDEA) model, a residue-level, in...

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Bibliographic Details
Main Authors: Yafan Zhang, Irene Silvernail, Zhuyang Lin, Xingcheng Lin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
data-driven modeling
structure-sequence integration
protein-DNA binding affinity prediction
genomic binding sites predictions
sequence-specific simulation
Online Access:https://elifesciences.org/articles/105565
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https://elifesciences.org/articles/105565

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