Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines
Encapsulated bacteria are responsible for the majority of mortality among neonates and infants. The major components on the surface of these bacteria are polysaccharides which are important virulence factors. Immunity against these components protects against disease. However, most of the polysaccha...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2008/628963 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564451013820416 |
|---|---|
| author | Peter Klein Klouwenberg Louis Bont |
| author_facet | Peter Klein Klouwenberg Louis Bont |
| author_sort | Peter Klein Klouwenberg |
| collection | DOAJ |
| description | Encapsulated bacteria are responsible for the majority of mortality among neonates and infants. The major components on the surface of these bacteria are polysaccharides which are important virulence factors. Immunity against these components protects against disease. However, most of the polysaccharides are thymus-independent (TI)-2 antigens which induce an inadequate immune response in neonates and infants. The mechanisms that are thought to play a role in the unresponsiveness of this age group to TI-2 stimuli will be discussed. The lack of immune response may be overcome by conjugating the polysaccharides to a carrier protein. This transforms bacterial polysaccharides from a TI-2 antigen into a thymus-dependent (TD) antigen, thereby inducing an immune response and immunological memory in neonates and infants. Such conjugated vaccines have been shown to be effective against the most common causes of invasive disease caused by encapsulated bacteria in neonates and children. These and several other approaches in current vaccine development will be discussed. |
| format | Article |
| id | doaj-art-1083e5fa77b04b99ad67cb050d5e6676 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1083e5fa77b04b99ad67cb050d5e66762025-02-03T01:10:56ZengWileyClinical and Developmental Immunology1740-25221740-25302008-01-01200810.1155/2008/628963628963Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate VaccinesPeter Klein Klouwenberg0Louis Bont1Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Centre, Room KE4.133.1, P.O. Box 85090, 3508 AB Utrecht, The NetherlandsDepartment of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Centre, Room KE4.133.1, P.O. Box 85090, 3508 AB Utrecht, The NetherlandsEncapsulated bacteria are responsible for the majority of mortality among neonates and infants. The major components on the surface of these bacteria are polysaccharides which are important virulence factors. Immunity against these components protects against disease. However, most of the polysaccharides are thymus-independent (TI)-2 antigens which induce an inadequate immune response in neonates and infants. The mechanisms that are thought to play a role in the unresponsiveness of this age group to TI-2 stimuli will be discussed. The lack of immune response may be overcome by conjugating the polysaccharides to a carrier protein. This transforms bacterial polysaccharides from a TI-2 antigen into a thymus-dependent (TD) antigen, thereby inducing an immune response and immunological memory in neonates and infants. Such conjugated vaccines have been shown to be effective against the most common causes of invasive disease caused by encapsulated bacteria in neonates and children. These and several other approaches in current vaccine development will be discussed.http://dx.doi.org/10.1155/2008/628963 |
| spellingShingle | Peter Klein Klouwenberg Louis Bont Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines Clinical and Developmental Immunology |
| title | Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines |
| title_full | Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines |
| title_fullStr | Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines |
| title_full_unstemmed | Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines |
| title_short | Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines |
| title_sort | neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines |
| url | http://dx.doi.org/10.1155/2008/628963 |
| work_keys_str_mv | AT peterkleinklouwenberg neonatalandinfantileimmuneresponsestoencapsulatedbacteriaandconjugatevaccines AT louisbont neonatalandinfantileimmuneresponsestoencapsulatedbacteriaandconjugatevaccines |