Antibiotic Therapy for Crohn’s Disease: A Review
Increasing evidence suggests that gut bacteria play a pathogenic role in Crohn’s disease (CD), providing a rationale for the use of antibiotics in the primary treatment of the disease. While there are data to suggest that antibiotics may be effective in treating active luminal, particularly colonic,...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2006/250490 |
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| _version_ | 1832562855719731200 |
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| author | Simon Lal A Hillary Steinhart |
| author_facet | Simon Lal A Hillary Steinhart |
| author_sort | Simon Lal |
| collection | DOAJ |
| description | Increasing evidence suggests that gut bacteria play a pathogenic role in Crohn’s disease (CD), providing a rationale for the use of antibiotics in the primary treatment of the disease. While there are data to suggest that antibiotics may be effective in treating active luminal, particularly colonic, and/or perianal CD, evidence for their use in these settings is hampered by the lack of well-designed, adequately powered, placebo-controlled trials. Furthermore, although nitroimidazole antibiotics have been shown to reduce postoperative recurrence following ileocolonic resection, their use is limited by side effects. There is a current need for rigorous multicentre studies looking into the role of antibiotics in treating perianal and luminal CD, as well as a need for the large-scale assessment of novel antibiotics, with low systemic absorption, which may improve patient tolerance. |
| format | Article |
| id | doaj-art-10815d9321744538a707cf819d29e3bc |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-10815d9321744538a707cf819d29e3bc2025-02-03T01:21:31ZengWileyCanadian Journal of Gastroenterology0835-79002006-01-01201065165510.1155/2006/250490Antibiotic Therapy for Crohn’s Disease: A ReviewSimon Lal0A Hillary Steinhart1Inflammatory Bowel Disease Centre, Mount Sinai Hospital, Toronto, Ontario, CanadaInflammatory Bowel Disease Centre, Mount Sinai Hospital, Toronto, Ontario, CanadaIncreasing evidence suggests that gut bacteria play a pathogenic role in Crohn’s disease (CD), providing a rationale for the use of antibiotics in the primary treatment of the disease. While there are data to suggest that antibiotics may be effective in treating active luminal, particularly colonic, and/or perianal CD, evidence for their use in these settings is hampered by the lack of well-designed, adequately powered, placebo-controlled trials. Furthermore, although nitroimidazole antibiotics have been shown to reduce postoperative recurrence following ileocolonic resection, their use is limited by side effects. There is a current need for rigorous multicentre studies looking into the role of antibiotics in treating perianal and luminal CD, as well as a need for the large-scale assessment of novel antibiotics, with low systemic absorption, which may improve patient tolerance.http://dx.doi.org/10.1155/2006/250490 |
| spellingShingle | Simon Lal A Hillary Steinhart Antibiotic Therapy for Crohn’s Disease: A Review Canadian Journal of Gastroenterology |
| title | Antibiotic Therapy for Crohn’s Disease: A Review |
| title_full | Antibiotic Therapy for Crohn’s Disease: A Review |
| title_fullStr | Antibiotic Therapy for Crohn’s Disease: A Review |
| title_full_unstemmed | Antibiotic Therapy for Crohn’s Disease: A Review |
| title_short | Antibiotic Therapy for Crohn’s Disease: A Review |
| title_sort | antibiotic therapy for crohn s disease a review |
| url | http://dx.doi.org/10.1155/2006/250490 |
| work_keys_str_mv | AT simonlal antibiotictherapyforcrohnsdiseaseareview AT ahillarysteinhart antibiotictherapyforcrohnsdiseaseareview |