The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies
Abstract In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major global health concern, PC contributes to high mortality rates and rising new cases worldwide, highlighting the urgent need for research into the molecular mechanisms beh...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01829-4 |
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| author | Ujjawal Sharma Anidrisha Sahu Himanshu Shekhar Bunty Sharma Shafiul Haque Damandeep Kaur Hardeep Singh Tuli Astha Mishra Faraz Ahmad |
| author_facet | Ujjawal Sharma Anidrisha Sahu Himanshu Shekhar Bunty Sharma Shafiul Haque Damandeep Kaur Hardeep Singh Tuli Astha Mishra Faraz Ahmad |
| author_sort | Ujjawal Sharma |
| collection | DOAJ |
| description | Abstract In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major global health concern, PC contributes to high mortality rates and rising new cases worldwide, highlighting the urgent need for research into the molecular mechanisms behind this disease. Notably, the persistence of inflammation actively promotes cancer development, including in PC. This review explores the complex relationship between inflammation and PC, examining the molecular pathways, genetic and environmental factors, and clinical implications involved in inflammation-driven carcinogenesis. From cellular and molecular elements of the inflammatory microenvironment to mechanisms like epithelial-to-mesenchymal transition (EMT), reactive oxygen species (ROS) generation, and inflammasome activation, these processes highlight inflammation’s influence on PC progression and metastasis. Furthermore, this review discusses current therapeutic strategies targeting inflammation in PC management and identifies future research directions aimed at unraveling the complexities of inflammation-induced PC (Supplementary Fig. 1). It defines the complex relationship between inflammation and PC, emphasizes the importance of targeting inflammation therapeutically and highlights innovative approaches in PC treatment. Graphical Abstract |
| format | Article |
| id | doaj-art-107f524c95c94205a06744589eeccd05 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-107f524c95c94205a06744589eeccd052025-02-02T12:30:32ZengSpringerDiscover Oncology2730-60112025-02-0116111910.1007/s12672-025-01829-4The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapiesUjjawal Sharma0Anidrisha Sahu1Himanshu Shekhar2Bunty Sharma3Shafiul Haque4Damandeep Kaur5Hardeep Singh Tuli6Astha Mishra7Faraz Ahmad8Department of Human Genetics and Molecular Medicine, Central University of PunjabDepartment of Human Genetics and Molecular Medicine, Central University of PunjabDepartment of Human Genetics and Molecular Medicine, Central University of PunjabDepartment of Biotechnology, Graphic Era (Deemed to be University)Research and Scientific Studies Unit, College of Nursing and Health Sciences, Jazan UniversityUniversity Centre for Research & Development, University Institute of Pharmaceutical Sciences, Chandigarh UniversityDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University)Department of Optometry, Chitkara School of Health Sciences, Chitkara UniversityDepartment of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of TechnologyAbstract In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major global health concern, PC contributes to high mortality rates and rising new cases worldwide, highlighting the urgent need for research into the molecular mechanisms behind this disease. Notably, the persistence of inflammation actively promotes cancer development, including in PC. This review explores the complex relationship between inflammation and PC, examining the molecular pathways, genetic and environmental factors, and clinical implications involved in inflammation-driven carcinogenesis. From cellular and molecular elements of the inflammatory microenvironment to mechanisms like epithelial-to-mesenchymal transition (EMT), reactive oxygen species (ROS) generation, and inflammasome activation, these processes highlight inflammation’s influence on PC progression and metastasis. Furthermore, this review discusses current therapeutic strategies targeting inflammation in PC management and identifies future research directions aimed at unraveling the complexities of inflammation-induced PC (Supplementary Fig. 1). It defines the complex relationship between inflammation and PC, emphasizes the importance of targeting inflammation therapeutically and highlights innovative approaches in PC treatment. Graphical Abstracthttps://doi.org/10.1007/s12672-025-01829-4Prostate cancerInflammationNF-κβP13K/AKTJAK/STATInflammatory microenvironment |
| spellingShingle | Ujjawal Sharma Anidrisha Sahu Himanshu Shekhar Bunty Sharma Shafiul Haque Damandeep Kaur Hardeep Singh Tuli Astha Mishra Faraz Ahmad The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies Discover Oncology Prostate cancer Inflammation NF-κβ P13K/AKT JAK/STAT Inflammatory microenvironment |
| title | The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies |
| title_full | The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies |
| title_fullStr | The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies |
| title_full_unstemmed | The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies |
| title_short | The heat of the battle: inflammation’s role in prostate cancer development and inflammation-targeted therapies |
| title_sort | heat of the battle inflammation s role in prostate cancer development and inflammation targeted therapies |
| topic | Prostate cancer Inflammation NF-κβ P13K/AKT JAK/STAT Inflammatory microenvironment |
| url | https://doi.org/10.1007/s12672-025-01829-4 |
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