Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis
Cytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals. Understanding CMV’s genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and deve...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/14/1/50 |
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| author | Cristina Venturini Judith Breuer |
| author_facet | Cristina Venturini Judith Breuer |
| author_sort | Cristina Venturini |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals. Understanding CMV’s genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and developing effective therapeutic interventions. This review provides a comprehensive examination of CMV’s genetic diversity and evolution, focussing on the role of different genotypes in viral pathogenesis. |
| format | Article |
| id | doaj-art-106cced9f7324a05b671aff42d8b4065 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-106cced9f7324a05b671aff42d8b40652025-01-24T13:44:43ZengMDPI AGPathogens2076-08172025-01-011415010.3390/pathogens14010050Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral PathogenesisCristina Venturini0Judith Breuer1Department of Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UKDepartment of Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UKCytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals. Understanding CMV’s genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and developing effective therapeutic interventions. This review provides a comprehensive examination of CMV’s genetic diversity and evolution, focussing on the role of different genotypes in viral pathogenesis.https://www.mdpi.com/2076-0817/14/1/50human cytomegalovirusgenotypeevolutionviral markers |
| spellingShingle | Cristina Venturini Judith Breuer Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis Pathogens human cytomegalovirus genotype evolution viral markers |
| title | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis |
| title_full | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis |
| title_fullStr | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis |
| title_full_unstemmed | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis |
| title_short | Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis |
| title_sort | cytomegalovirus genetic diversity and evolution insights into genotypes and their role in viral pathogenesis |
| topic | human cytomegalovirus genotype evolution viral markers |
| url | https://www.mdpi.com/2076-0817/14/1/50 |
| work_keys_str_mv | AT cristinaventurini cytomegalovirusgeneticdiversityandevolutioninsightsintogenotypesandtheirroleinviralpathogenesis AT judithbreuer cytomegalovirusgeneticdiversityandevolutioninsightsintogenotypesandtheirroleinviralpathogenesis |