Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells
Cancer is a global burden that has prompted extensive research into prevention and treatment, over many decades. Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis, metastasis, drug resistance, and recurrences. CS...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Optics |
| Online Access: | http://dx.doi.org/10.1155/2018/7317063 |
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| _version_ | 1832555255812849664 |
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| author | Anine Crous Elvin Chizenga Natasha Hodgkinson Heidi Abrahamse |
| author_facet | Anine Crous Elvin Chizenga Natasha Hodgkinson Heidi Abrahamse |
| author_sort | Anine Crous |
| collection | DOAJ |
| description | Cancer is a global burden that has prompted extensive research into prevention and treatment, over many decades. Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis, metastasis, drug resistance, and recurrences. CSCs have characteristic features of enhanced self-renewal, proliferation, and limited but multidirectional differentiation capacity. The discovery of CSCs has initiated extensive research into novel cancer treatment regimes. Evidence indicates that CSCs are resistant to conventional chemo- and radiation therapy leading to treatment failures, cancer metastasis, secondary cancer formation, and relapse. Because of the observed phenomena in the course of cancer prognosis, a need for treatment modalities targeting CSCs is important. Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells. It uses a photosensitizer (PS) that becomes excited when subjected to light at a specific wavelength, and the PS forms reactive oxygen species (ROS) killing malignant cells. Currently, PDT is being investigated as a target specific treatment for CSCs by the addition of carrier molecules and antibody conjugates bound to the PS. Targeted PDT (TPDT) may be able to not only eradicate the tumour mass but kill CSCs as well. |
| format | Article |
| id | doaj-art-106329a0beef41a5a6521c04f85ca888 |
| institution | Kabale University |
| issn | 1687-9384 1687-9392 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Optics |
| spelling | doaj-art-106329a0beef41a5a6521c04f85ca8882025-02-03T05:48:39ZengWileyInternational Journal of Optics1687-93841687-93922018-01-01201810.1155/2018/73170637317063Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem CellsAnine Crous0Elvin Chizenga1Natasha Hodgkinson2Heidi Abrahamse3Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, Room 5308, John Orr Building, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, Room 5308, John Orr Building, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, Room 5308, John Orr Building, South AfricaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg 2028, Room 5308, John Orr Building, South AfricaCancer is a global burden that has prompted extensive research into prevention and treatment, over many decades. Scientific studies have shown that subset of cells within a tumour, known as cancer stem cells (CSCs), are responsible for tumourigenesis, metastasis, drug resistance, and recurrences. CSCs have characteristic features of enhanced self-renewal, proliferation, and limited but multidirectional differentiation capacity. The discovery of CSCs has initiated extensive research into novel cancer treatment regimes. Evidence indicates that CSCs are resistant to conventional chemo- and radiation therapy leading to treatment failures, cancer metastasis, secondary cancer formation, and relapse. Because of the observed phenomena in the course of cancer prognosis, a need for treatment modalities targeting CSCs is important. Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells. It uses a photosensitizer (PS) that becomes excited when subjected to light at a specific wavelength, and the PS forms reactive oxygen species (ROS) killing malignant cells. Currently, PDT is being investigated as a target specific treatment for CSCs by the addition of carrier molecules and antibody conjugates bound to the PS. Targeted PDT (TPDT) may be able to not only eradicate the tumour mass but kill CSCs as well.http://dx.doi.org/10.1155/2018/7317063 |
| spellingShingle | Anine Crous Elvin Chizenga Natasha Hodgkinson Heidi Abrahamse Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells International Journal of Optics |
| title | Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells |
| title_full | Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells |
| title_fullStr | Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells |
| title_full_unstemmed | Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells |
| title_short | Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells |
| title_sort | targeted photodynamic therapy a novel approach to abolition of human cancer stem cells |
| url | http://dx.doi.org/10.1155/2018/7317063 |
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