Contribution of Statins towards Periodontal Treatment: A Review
The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6367402 |
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| _version_ | 1832556795119271936 |
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| author | Catherine Petit Fareeha Batool Isaac Maximiliano Bugueno Pascale Schwinté Nadia Benkirane-Jessel Olivier Huck |
| author_facet | Catherine Petit Fareeha Batool Isaac Maximiliano Bugueno Pascale Schwinté Nadia Benkirane-Jessel Olivier Huck |
| author_sort | Catherine Petit |
| collection | DOAJ |
| description | The pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-κB pathways. Moreover, they are able to modulate the host response activated by bacterial challenge, to prevent inflammation-mediated bone resorption and to promote bone formation. Furthermore, they reduce bacterial growth, disrupt bacterial membrane stability, and increase bacterial clearance, thus averting the exacerbation of infection. Local statin delivery as adjunct to both nonsurgical and surgical periodontal therapies results in better periodontal treatment outcomes compared to systemic delivery. Moreover, combination of statin therapy with other regenerative agents improves periodontal healing response. Therefore, statins could be proposed as a potential adjuvant to periodontal therapy. However, optimization of the combination of their dose, type, and carrier could be instrumental in achieving the best treatment response. |
| format | Article |
| id | doaj-art-1057da7ffae54b46a32948ded394f615 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1057da7ffae54b46a32948ded394f6152025-02-03T05:44:23ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/63674026367402Contribution of Statins towards Periodontal Treatment: A ReviewCatherine Petit0Fareeha Batool1Isaac Maximiliano Bugueno2Pascale Schwinté3Nadia Benkirane-Jessel4Olivier Huck5INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceINSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceINSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceINSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceINSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceINSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceThe pleiotropic effects of statins have been evaluated to assess their potential benefit in the treatment of various inflammatory and immune-mediated diseases including periodontitis. Herein, the adjunctive use of statins in periodontal therapy in vitro, in vivo, and in clinical trials was reviewed. Statins act through several pathways to modulate inflammation, immune response, bone metabolism, and bacterial clearance. They control periodontal inflammation through inhibition of proinflammatory cytokines and promotion of anti-inflammatory and/or proresolution molecule release, mainly, through the ERK, MAPK, PI3-Akt, and NF-κB pathways. Moreover, they are able to modulate the host response activated by bacterial challenge, to prevent inflammation-mediated bone resorption and to promote bone formation. Furthermore, they reduce bacterial growth, disrupt bacterial membrane stability, and increase bacterial clearance, thus averting the exacerbation of infection. Local statin delivery as adjunct to both nonsurgical and surgical periodontal therapies results in better periodontal treatment outcomes compared to systemic delivery. Moreover, combination of statin therapy with other regenerative agents improves periodontal healing response. Therefore, statins could be proposed as a potential adjuvant to periodontal therapy. However, optimization of the combination of their dose, type, and carrier could be instrumental in achieving the best treatment response.http://dx.doi.org/10.1155/2019/6367402 |
| spellingShingle | Catherine Petit Fareeha Batool Isaac Maximiliano Bugueno Pascale Schwinté Nadia Benkirane-Jessel Olivier Huck Contribution of Statins towards Periodontal Treatment: A Review Mediators of Inflammation |
| title | Contribution of Statins towards Periodontal Treatment: A Review |
| title_full | Contribution of Statins towards Periodontal Treatment: A Review |
| title_fullStr | Contribution of Statins towards Periodontal Treatment: A Review |
| title_full_unstemmed | Contribution of Statins towards Periodontal Treatment: A Review |
| title_short | Contribution of Statins towards Periodontal Treatment: A Review |
| title_sort | contribution of statins towards periodontal treatment a review |
| url | http://dx.doi.org/10.1155/2019/6367402 |
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