Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s
Introduction: Sex-based differences in histological subtypes, in frequencies of mutations, and differences in response to the various therapeutic approaches in lung cancer are well studied. In general, the literature is controversial, and the large majority of the investigations may not provide evid...
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004694 |
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| author | Berta Mosleh Pavla Sarova Sonja Zehetmayer Felicitas Oberndorfer Joachim Widder Helmut Prosch Marco Idzko Clemens Aigner Mir Alireza Hoda Daniela Gompelmann |
| author_facet | Berta Mosleh Pavla Sarova Sonja Zehetmayer Felicitas Oberndorfer Joachim Widder Helmut Prosch Marco Idzko Clemens Aigner Mir Alireza Hoda Daniela Gompelmann |
| author_sort | Berta Mosleh |
| collection | DOAJ |
| description | Introduction: Sex-based differences in histological subtypes, in frequencies of mutations, and differences in response to the various therapeutic approaches in lung cancer are well studied. In general, the literature is controversial, and the large majority of the investigations may not provide evidence from the last decade. Objective: The objective of the current study was to reveal timely sex-based differences in patients with lung cancer in the era of immunotherapy and molecularly targeted agents. Methods: We retrospectively analyzed a consecutive cohort of 286 patients (female:male ratio 134:152/47 %:53 %) who were diagnosed with lung cancer between 2020 and 2022 in the pulmonology department of the Medical University of Vienna, Austria. Demographic characteristics, histological subtypes, the PD-L1 expression on tumor cells, presence of mutations, treatment, and survival of male and female patients were compared. Results: The smoking rate in women with lung cancer was significantly lower than in men (p = 0.005). The rate of targetable mutations was significantly higher in female patients (52 % vs. 30 %, p = 0.011). There were no significant differences in age at diagnosis, body mass index, lung function parameters, histological subtypes, PD-L1 protein expression, disease stage, and survival between men and women (all p > 0.05). Conclusion: Female Caucasian patients seem to have a higher susceptibility to lung cancer. Although the rate of genetic alterations is similar in both sexes, actionable driver mutations are significantly more common in women. |
| format | Article |
| id | doaj-art-1046c63b8f064777aa885d7b7ef9202b |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-1046c63b8f064777aa885d7b7ef9202b2025-02-02T05:28:57ZengElsevierHeliyon2405-84402025-01-01112e42089Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020sBerta Mosleh0Pavla Sarova1Sonja Zehetmayer2Felicitas Oberndorfer3Joachim Widder4Helmut Prosch5Marco Idzko6Clemens Aigner7Mir Alireza Hoda8Daniela Gompelmann9Department of Thoracic Surgery, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDivision of Pulmonology, Department of Internal Medicine II, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaCenter for Medical Data Science, Medical University of Vienna, AustriaDepartment of Pathology, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDepartment of Radiation Oncology, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDepartment of Biomedical Imaging and Image-guided Therapy, Comprehensive Cancer Center Vienna, Medical University of Vienna, AustriaDivision of Pulmonology, Department of Internal Medicine II, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDepartment of Thoracic Surgery, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDepartment of Thoracic Surgery, Comprehensive Cancer Center Vienna, Medical University Vienna, AustriaDivision of Pulmonology, Department of Internal Medicine II, Comprehensive Cancer Center Vienna, Medical University Vienna, Austria; Corresponding author.Introduction: Sex-based differences in histological subtypes, in frequencies of mutations, and differences in response to the various therapeutic approaches in lung cancer are well studied. In general, the literature is controversial, and the large majority of the investigations may not provide evidence from the last decade. Objective: The objective of the current study was to reveal timely sex-based differences in patients with lung cancer in the era of immunotherapy and molecularly targeted agents. Methods: We retrospectively analyzed a consecutive cohort of 286 patients (female:male ratio 134:152/47 %:53 %) who were diagnosed with lung cancer between 2020 and 2022 in the pulmonology department of the Medical University of Vienna, Austria. Demographic characteristics, histological subtypes, the PD-L1 expression on tumor cells, presence of mutations, treatment, and survival of male and female patients were compared. Results: The smoking rate in women with lung cancer was significantly lower than in men (p = 0.005). The rate of targetable mutations was significantly higher in female patients (52 % vs. 30 %, p = 0.011). There were no significant differences in age at diagnosis, body mass index, lung function parameters, histological subtypes, PD-L1 protein expression, disease stage, and survival between men and women (all p > 0.05). Conclusion: Female Caucasian patients seem to have a higher susceptibility to lung cancer. Although the rate of genetic alterations is similar in both sexes, actionable driver mutations are significantly more common in women.http://www.sciencedirect.com/science/article/pii/S2405844025004694Lung cancerSex-based differencesLung cancer susceptibility |
| spellingShingle | Berta Mosleh Pavla Sarova Sonja Zehetmayer Felicitas Oberndorfer Joachim Widder Helmut Prosch Marco Idzko Clemens Aigner Mir Alireza Hoda Daniela Gompelmann Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s Heliyon Lung cancer Sex-based differences Lung cancer susceptibility |
| title | Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| title_full | Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| title_fullStr | Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| title_full_unstemmed | Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| title_short | Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| title_sort | sex based differences in lung cancer susceptibility and molecular genetics in the 2020s |
| topic | Lung cancer Sex-based differences Lung cancer susceptibility |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004694 |
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