Angiogenesis and Its Therapeutic Opportunities
Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matri...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/127170 |
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| _version_ | 1832564170650812416 |
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| author | So Young Yoo Sang Mo Kwon |
| author_facet | So Young Yoo Sang Mo Kwon |
| author_sort | So Young Yoo |
| collection | DOAJ |
| description | Angiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases. |
| format | Article |
| id | doaj-art-104619bacf0b466fabcd1cf61fd3e95f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-104619bacf0b466fabcd1cf61fd3e95f2025-02-03T01:11:34ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/127170127170Angiogenesis and Its Therapeutic OpportunitiesSo Young Yoo0Sang Mo Kwon1Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626-870, Republic of KoreaLaboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan 626-870, Republic of KoreaAngiogenesis plays critical roles in human physiology that range from reproduction and fetal growth to wound healing and tissue repair. The sophisticated multistep process is tightly regulated in a spatial and temporal manner by “on-off switch signals” between angiogenic factors, extracellular matrix components, and endothelial cells. Uncontrolled angiogenesis may lead to several angiogenic disorders, including vascular insufficiency (myocardial or critical limb ischemia) and vascular overgrowth (hemangiomas, vascularized tumors, and retinopathies). Thus, numerous therapeutic opportunities can be envisaged through the successful understanding and subsequent manipulation of angiogenesis. Here, we review the clinical implications of angiogenesis and discuss pro- and antiangiogenic agents that offer potential therapy for cancer and other angiogenic diseases.http://dx.doi.org/10.1155/2013/127170 |
| spellingShingle | So Young Yoo Sang Mo Kwon Angiogenesis and Its Therapeutic Opportunities Mediators of Inflammation |
| title | Angiogenesis and Its Therapeutic Opportunities |
| title_full | Angiogenesis and Its Therapeutic Opportunities |
| title_fullStr | Angiogenesis and Its Therapeutic Opportunities |
| title_full_unstemmed | Angiogenesis and Its Therapeutic Opportunities |
| title_short | Angiogenesis and Its Therapeutic Opportunities |
| title_sort | angiogenesis and its therapeutic opportunities |
| url | http://dx.doi.org/10.1155/2013/127170 |
| work_keys_str_mv | AT soyoungyoo angiogenesisanditstherapeuticopportunities AT sangmokwon angiogenesisanditstherapeuticopportunities |