“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review

“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review

ABSTRACT Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of lat...

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Bibliographic Details
Main Authors: Clement Tan, Vaikunthan Thanabalasingam, Chaminda Sella Kapu, Zhihua Zhang
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical Case Reports
Subjects:
congenital
genotype
genotype negative
implanted cardiac defibrillator
late onset
long QT syndrome
Online Access:https://doi.org/10.1002/ccr3.70201
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Summary:ABSTRACT Congenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of late‐onset genotype‐negative phenotype‐positive LQTS presenting as palpitations, complicated by a single event of polymorphic ventricular tachycardia, followed by a review of the literature. This case underscores the gaps in understanding congenital long QT syndrome, especially in genotype‐negative cases, and highlights the need for ongoing research for risk assessment and effective management to prevent fatal cardiac events.
ISSN:2050-0904

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