S‐PLM: Structure‐Aware Protein Language Model via Contrastive Learning Between Sequence and Structure

S‐PLM: Structure‐Aware Protein Language Model via Contrastive Learning Between Sequence and Structure

Abstract Proteins play an essential role in various biological and engineering processes. Large protein language models (PLMs) present excellent potential to reshape protein research by accelerating the determination of protein functions and the design of proteins with the desired functions. The pre...

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Bibliographic Details
Main Authors: Duolin Wang, Mahdi Pourmirzaei, Usman L. Abbas, Shuai Zeng, Negin Manshour, Farzaneh Esmaili, Biplab Poudel, Yuexu Jiang, Qing Shao, Jin Chen, Dong Xu
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
contrastive learning
deep learning
protein function prediction
protein language model
protein structure
Online Access:https://doi.org/10.1002/advs.202404212
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