HLA-G Dimers in the Prolongation of Kidney Allograft Survival
Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rej...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/153981 |
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| author | Maureen Ezeakile Vera Portik-Dobos Juan Wu Daniel D. Horuzsko Rajan Kapoor Muralidharan Jagadeesan Laura L. Mulloy Anatolij Horuzsko |
| author_facet | Maureen Ezeakile Vera Portik-Dobos Juan Wu Daniel D. Horuzsko Rajan Kapoor Muralidharan Jagadeesan Laura L. Mulloy Anatolij Horuzsko |
| author_sort | Maureen Ezeakile |
| collection | DOAJ |
| description | Human leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rejection of allogeneic tissue/organ. Current models of the interactions of HLA-G and its specific receptors explain it as functioning in a monomeric form. However, in recent years, new data has revealed the ability of HLA-G to form disulfide-linked dimeric complexes with high preferential binding and functional activities. Limited data are available on the role of soluble HLA-G dimers in clinical pathological conditions. We describe here the presence of soluble HLA-G dimers in kidney transplant patients. Our study showed that a high level of HLA-G dimers in plasma and increased expression of the membrane-bound form of HLA-G on monocytes are associated with prolongation of kidney allograft survival. We also determined that the presence of soluble HLA-G dimers links to the lower levels of proinflammatory cytokines, suggesting a potential role of HLA-G dimers in controlling the accompanying inflammatory state. |
| format | Article |
| id | doaj-art-101653fc891649d6bd05b0c00e86ba5f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-101653fc891649d6bd05b0c00e86ba5f2025-02-03T00:59:09ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/153981153981HLA-G Dimers in the Prolongation of Kidney Allograft SurvivalMaureen Ezeakile0Vera Portik-Dobos1Juan Wu2Daniel D. Horuzsko3Rajan Kapoor4Muralidharan Jagadeesan5Laura L. Mulloy6Anatolij Horuzsko7Molecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USAMolecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USAMolecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USAMolecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USASection of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USASection of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USASection of Nephrology, Hypertension, and Transplantation Medicine, Department of Medicine, Georgia Regents University, Augusta, GA 30912, USAMolecular Oncology and Biomarkers Program, Cancer Center, Department of Medicine, Georgia Regents University, 1410 Laney Walker Boulevard, Augusta, GA 30912, USAHuman leukocyte antigen-G (HLA-G) contributes to acceptance of allografts in solid organ/tissue transplantation. Most studies have determined that soluble HLA-G isoforms are systematically detected in serum/plasma of transplanted patients with significantly fewer episodes of acute and/or chronic rejection of allogeneic tissue/organ. Current models of the interactions of HLA-G and its specific receptors explain it as functioning in a monomeric form. However, in recent years, new data has revealed the ability of HLA-G to form disulfide-linked dimeric complexes with high preferential binding and functional activities. Limited data are available on the role of soluble HLA-G dimers in clinical pathological conditions. We describe here the presence of soluble HLA-G dimers in kidney transplant patients. Our study showed that a high level of HLA-G dimers in plasma and increased expression of the membrane-bound form of HLA-G on monocytes are associated with prolongation of kidney allograft survival. We also determined that the presence of soluble HLA-G dimers links to the lower levels of proinflammatory cytokines, suggesting a potential role of HLA-G dimers in controlling the accompanying inflammatory state.http://dx.doi.org/10.1155/2014/153981 |
| spellingShingle | Maureen Ezeakile Vera Portik-Dobos Juan Wu Daniel D. Horuzsko Rajan Kapoor Muralidharan Jagadeesan Laura L. Mulloy Anatolij Horuzsko HLA-G Dimers in the Prolongation of Kidney Allograft Survival Journal of Immunology Research |
| title | HLA-G Dimers in the Prolongation of Kidney Allograft Survival |
| title_full | HLA-G Dimers in the Prolongation of Kidney Allograft Survival |
| title_fullStr | HLA-G Dimers in the Prolongation of Kidney Allograft Survival |
| title_full_unstemmed | HLA-G Dimers in the Prolongation of Kidney Allograft Survival |
| title_short | HLA-G Dimers in the Prolongation of Kidney Allograft Survival |
| title_sort | hla g dimers in the prolongation of kidney allograft survival |
| url | http://dx.doi.org/10.1155/2014/153981 |
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