Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination
An increase in peroxidation activity is considered as a nonspecific process characteristic of the pathogenesis of various diseases accompanied by antioxidant deficiency. As bioregulators that can increase defense, antioxidants are important links in a multi-stage system of regulation and coordinatio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Siberian Branch Publishing House
2022-06-01
|
| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/799 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849318837637349376 |
|---|---|
| author | O. A. Nikitina M. A. Darenskaya N. V. Semenova L. I. Kolesnikova |
| author_facet | O. A. Nikitina M. A. Darenskaya N. V. Semenova L. I. Kolesnikova |
| author_sort | O. A. Nikitina |
| collection | DOAJ |
| description | An increase in peroxidation activity is considered as a nonspecific process characteristic of the pathogenesis of various diseases accompanied by antioxidant deficiency. As bioregulators that can increase defense, antioxidants are important links in a multi-stage system of regulation and coordination of various body functions. The structure and function of enzymes involved in the regulation of oxidative stress can be significantly affected by genetic polymorphism. To date, the role of genes encoding the activity of enzymes of the antioxidant system in the pathogenesis of many diseases remains unexplored, which is of great interest to researchers from various fields. The article presents a review and analysis of data from modern scientific literature on the role of antioxidant defense components in the regulation of metabolic processes, their genetic determinant, and summarizes data on modern methods for the determination of some antioxidants. When writing the review, the database of the scientific electronic library eLibrary was used, the keywords are oxidative stress, free radical oxidation, antioxidant protection, antioxidants, antioxidant enzymes, enzyme genes, antioxidant response element, research methods; filters – publication years 2012–2022, publications with full text, publications available for viewing; English-language database of medical and biological publications, created by the National Center for Biotechnology Information (NCBI), keywords – lipid peroxidation, antioxidant protection, antioxidants, antioxidant enzymes, enzyme genes, oxidative stress, metabolism, methods. |
| format | Article |
| id | doaj-art-1015bf12b7bd4a1599c2a7f0c6f87485 |
| institution | Kabale University |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2022-06-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-1015bf12b7bd4a1599c2a7f0c6f874852025-08-20T03:50:44ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202022-06-0142341710.18699/SSMJ20220301419Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determinationO. A. Nikitina0M. A. Darenskaya1N. V. Semenova2L. I. Kolesnikova3Scientific Center for Family Health and Human ReproductionScientific Center for Family Health and Human ReproductionScientific Center for Family Health and Human ReproductionScientific Center for Family Health and Human ReproductionмAn increase in peroxidation activity is considered as a nonspecific process characteristic of the pathogenesis of various diseases accompanied by antioxidant deficiency. As bioregulators that can increase defense, antioxidants are important links in a multi-stage system of regulation and coordination of various body functions. The structure and function of enzymes involved in the regulation of oxidative stress can be significantly affected by genetic polymorphism. To date, the role of genes encoding the activity of enzymes of the antioxidant system in the pathogenesis of many diseases remains unexplored, which is of great interest to researchers from various fields. The article presents a review and analysis of data from modern scientific literature on the role of antioxidant defense components in the regulation of metabolic processes, their genetic determinant, and summarizes data on modern methods for the determination of some antioxidants. When writing the review, the database of the scientific electronic library eLibrary was used, the keywords are oxidative stress, free radical oxidation, antioxidant protection, antioxidants, antioxidant enzymes, enzyme genes, antioxidant response element, research methods; filters – publication years 2012–2022, publications with full text, publications available for viewing; English-language database of medical and biological publications, created by the National Center for Biotechnology Information (NCBI), keywords – lipid peroxidation, antioxidant protection, antioxidants, antioxidant enzymes, enzyme genes, oxidative stress, metabolism, methods.https://sibmed.elpub.ru/jour/article/view/799oxidative stressfree radical oxidationantioxidantsantioxidant enzymesenzyme genesmethods |
| spellingShingle | O. A. Nikitina M. A. Darenskaya N. V. Semenova L. I. Kolesnikova Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination Сибирский научный медицинский журнал oxidative stress free radical oxidation antioxidants antioxidant enzymes enzyme genes methods |
| title | Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination |
| title_full | Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination |
| title_fullStr | Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination |
| title_full_unstemmed | Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination |
| title_short | Antioxidant defense system: regulation of metabolic processes, genetic determinants, methods of determination |
| title_sort | antioxidant defense system regulation of metabolic processes genetic determinants methods of determination |
| topic | oxidative stress free radical oxidation antioxidants antioxidant enzymes enzyme genes methods |
| url | https://sibmed.elpub.ru/jour/article/view/799 |
| work_keys_str_mv | AT oanikitina antioxidantdefensesystemregulationofmetabolicprocessesgeneticdeterminantsmethodsofdetermination AT madarenskaya antioxidantdefensesystemregulationofmetabolicprocessesgeneticdeterminantsmethodsofdetermination AT nvsemenova antioxidantdefensesystemregulationofmetabolicprocessesgeneticdeterminantsmethodsofdetermination AT likolesnikova antioxidantdefensesystemregulationofmetabolicprocessesgeneticdeterminantsmethodsofdetermination |