Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor
Periodontal bone defects pose significant challenges in dentistry, necessitating effective treatment strategies. This case report explores the regenerative potential of using a combination of particulate dentin graft (PDG) derived from extracted teeth and recombinant human platelet-derived growth fa...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-07-01
|
| Series: | Journal of Indian Society of Periodontology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jisp.jisp_449_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087087044624384 |
|---|---|
| author | Vishal Garg Amit Bhardwaj Kirti Chawla |
| author_facet | Vishal Garg Amit Bhardwaj Kirti Chawla |
| author_sort | Vishal Garg |
| collection | DOAJ |
| description | Periodontal bone defects pose significant challenges in dentistry, necessitating effective treatment strategies. This case report explores the regenerative potential of using a combination of particulate dentin graft (PDG) derived from extracted teeth and recombinant human platelet-derived growth factor (rhPDGF) as bone graft material for the treatment of human periodontal infrabony defects. A 44-year-old male patient presented with a 9 mm pocket probing depth (PPD) and an 8 mm infrabony defect depth mesial to #13, with no gingival recession (GR). Following Phase I therapy, open flap debridement and grafting with PDG and rhPDGF were performed. Clinical and radiographic measurements were taken at baseline and 6 and 12 months. At 12 months, a 6 mm reduction in PPD and clinical attachment level gain were observed with no GR. 5 mm (83.33%) bone fill was seen radiographically. Within the limitations of this case report, the utilization of PDG with rhPDGF for the treatment of infrabony periodontal defects has emerged as a promising regenerative therapy. |
| format | Article |
| id | doaj-art-1011c67b43e642099fc211d9160c0ba6 |
| institution | Kabale University |
| issn | 0972-124X 0975-1580 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Society of Periodontology |
| spelling | doaj-art-1011c67b43e642099fc211d9160c0ba62025-02-06T07:19:22ZengWolters Kluwer Medknow PublicationsJournal of Indian Society of Periodontology0972-124X0975-15802024-07-0128448949310.4103/jisp.jisp_449_23Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factorVishal GargAmit BhardwajKirti ChawlaPeriodontal bone defects pose significant challenges in dentistry, necessitating effective treatment strategies. This case report explores the regenerative potential of using a combination of particulate dentin graft (PDG) derived from extracted teeth and recombinant human platelet-derived growth factor (rhPDGF) as bone graft material for the treatment of human periodontal infrabony defects. A 44-year-old male patient presented with a 9 mm pocket probing depth (PPD) and an 8 mm infrabony defect depth mesial to #13, with no gingival recession (GR). Following Phase I therapy, open flap debridement and grafting with PDG and rhPDGF were performed. Clinical and radiographic measurements were taken at baseline and 6 and 12 months. At 12 months, a 6 mm reduction in PPD and clinical attachment level gain were observed with no GR. 5 mm (83.33%) bone fill was seen radiographically. Within the limitations of this case report, the utilization of PDG with rhPDGF for the treatment of infrabony periodontal defects has emerged as a promising regenerative therapy.https://journals.lww.com/10.4103/jisp.jisp_449_23demineralized dentin matrixhuman-recombinant platelet-derived growth factorparticulate dentin graftperiodontal infrabony defect |
| spellingShingle | Vishal Garg Amit Bhardwaj Kirti Chawla Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor Journal of Indian Society of Periodontology demineralized dentin matrix human-recombinant platelet-derived growth factor particulate dentin graft periodontal infrabony defect |
| title | Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor |
| title_full | Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor |
| title_fullStr | Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor |
| title_full_unstemmed | Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor |
| title_short | Treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet-derived growth factor |
| title_sort | treatment of periodontal infrabony defect using particulate dentin graft and recombinant human platelet derived growth factor |
| topic | demineralized dentin matrix human-recombinant platelet-derived growth factor particulate dentin graft periodontal infrabony defect |
| url | https://journals.lww.com/10.4103/jisp.jisp_449_23 |
| work_keys_str_mv | AT vishalgarg treatmentofperiodontalinfrabonydefectusingparticulatedentingraftandrecombinanthumanplateletderivedgrowthfactor AT amitbhardwaj treatmentofperiodontalinfrabonydefectusingparticulatedentingraftandrecombinanthumanplateletderivedgrowthfactor AT kirtichawla treatmentofperiodontalinfrabonydefectusingparticulatedentingraftandrecombinanthumanplateletderivedgrowthfactor |